[Intensive chemotherapy in the treatment of patients with metastatic breast cancer].

Szczegóły
Abstrakt

Tytuł:: [Intensive chemotherapy in the treatment of patients with metastatic breast cancer].
Autorzy:: Salgado JE; Departamento de Oncología, Facultad de Medicina, Universidad de Navarra.
Aramendía JM
Fernández-Hidalgo OA
Lozano E
Rebollo J
Martínez-Monge R
Subirá ML
Brugarolas A
Transliterated Title:: Quimioterapia intensiva en el tratamiento de pacientes con cáncer de mama metastásico.
Źródło:: Revista de medicina de la Universidad de Navarra [Rev Med Univ Navarra] 1997 Jul-Sep; Vol. 41 (3), pp. 143-51.
Typ publikacji:: English Abstract; Journal Article
Język:: Spanish; Castilian
Imprint Name(s):: Original Publication: Pamplona : Universidad De Navarra. Facultad De Medicina
MeSH Terms:: Salvage Therapy*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Breast Neoplasms/*drug therapy
Carcinoma, Ductal, Breast/*drug therapy
Carcinoma, Ductal, Breast/*secondary
Neoplasm Metastasis/*drug therapy
Acute Kidney Injury/chemically induced ; Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bone Marrow Diseases/chemically induced ; Bone Marrow Diseases/therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Carboplatin/administration & dosage ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/therapy ; Combined Modality Therapy ; Cyclophosphamide/administration & dosage ; Disease Progression ; Disease-Free Survival ; Etoposide/administration & dosage ; Female ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hepatic Veno-Occlusive Disease/chemically induced ; Humans ; Life Tables ; Middle Aged ; Mitoxantrone/administration & dosage ; Neoplasm Metastasis/therapy ; Neoplasms, Hormone-Dependent/drug therapy ; Neoplasms, Hormone-Dependent/mortality ; Neoplasms, Hormone-Dependent/secondary ; Neoplasms, Hormone-Dependent/therapy ; Radiotherapy, Adjuvant ; Remission Induction ; Sepsis/etiology ; Shock, Cardiogenic/etiology ; Survival Rate ; Thiotepa/administration & dosage ; Treatment Outcome
Substance Nomenclature:: 6PLQ3CP4P3 (Etoposide)
8N3DW7272P (Cyclophosphamide)
905Z5W3GKH (Thiotepa)
BG3F62OND5 (Carboplatin)
BZ114NVM5P (Mitoxantrone)
Entry Date(s):: Date Created: 19970701 Date Completed: 19991021 Latest Revision: 20131121
Update Code:: 20240104
PMID:: 10420919
: Czasopismo naukowe

Purpose: Phase II study with intensive chemotherapy and autologous stem cells support in patients with metastatic breast cancer.
Methods: Forty-nine patients were treated with high-doses of two cytotoxic drugs and support with stem cells obtained from several leukapheresis without movilitation. The cells were reinfused forty-eight hours after finishing the administration of chemotherapy.
Results: Twenty-one patients (47%, CI-95%: 32.4-63.3%) achieved a complete remission. The objective responses rate was 73% (CI-95%: 57.2-85%). Overall and progression-free survival up to 4 years were 31% and 20%, respectively. Ten patients remain progression-free among 17 and 46 months. The most frequent extramedullary toxicity was hepatic and renal. Three patients (6%) died during the procedure.
Conclusions: Intensive chemotherapy with hematopoietic support yields, with a moderate toxicity, a high objective response and complete remission rate. A small group of patients achieves a long progression-free survival.

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