A case of inv(8)(p11q24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16).

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Abstrakt

Tytuł:: A case of inv(8)(p11q24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16).
Autorzy:: Chaffanet M; Laboratoire d'Oncologie Moléculaire, U.119 INSERM, Marseille, France.
Mozziconacci MJ
Fernandez F
Sainty D
Lafage-Pochitaloff M
Birnbaum D
Pébusque MJ
Źródło:: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 1999 Oct; Vol. 26 (2), pp. 161-5.
Typ publikacji:: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: New York, NY : Wiley-Liss
Original Publication: New York : A.R. Liss, c1989-
MeSH Terms:: Chromosome Inversion*
Acetyltransferases/*genetics
Chromosomes, Human, Pair 16/*genetics
Chromosomes, Human, Pair 8/*genetics
Leukemia, Myeloid, Acute/*genetics
Nuclear Proteins/*genetics
Trans-Activators/*genetics
Translocation, Genetic/*genetics
CREB-Binding Protein ; Cyclic AMP Response Element-Binding Protein/genetics ; Female ; Histone Acetyltransferases ; Humans ; Middle Aged
Substance Nomenclature:: 0 (Cyclic AMP Response Element-Binding Protein)
0 (Nuclear Proteins)
0 (Trans-Activators)
EC 2.3.1.- (Acetyltransferases)
EC 2.3.1.48 (CREB-Binding Protein)
EC 2.3.1.48 (CREBBP protein, human)
EC 2.3.1.48 (Histone Acetyltransferases)
EC 2.3.1.48 (KAT6A protein, human)
Entry Date(s):: Date Created: 19990901 Date Completed: 20000107 Latest Revision: 20161124
Update Code:: 20240104
PMID:: 10469454
: Czasopismo naukowe

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We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 16p13 chromosomal regions. The breakpoints occur in the MOZ region encoding the acidic domain and in the 5' end of the CBP gene. These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias. Genes Chromosomes Cancer 26:161-165, 1999.
(Copyright 1999 Wiley-Liss, Inc.)

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