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Tytuł pozycji:

Specialized ability of thymic epithelial cells to mediate positive selection does not require expression of the steroidogenic enzyme p450scc.

Tytuł :
Specialized ability of thymic epithelial cells to mediate positive selection does not require expression of the steroidogenic enzyme p450scc.
Autorzy :
Jenkinson EJ; Department of Anatomy, Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom. />Parnell S
Shuttleworth J
Owen JJ
Anderson G
Pokaż więcej
Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1999 Dec 01; Vol. 163 (11), pp. 5781-5.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Bethesda, MD : American Association of Immunologists
Original Publication: Baltimore : Williams & Wilkins, c1950-
MeSH Terms :
Cholesterol Side-Chain Cleavage Enzyme/*biosynthesis
Epithelial Cells/*immunology
Glucocorticoids/*metabolism
Thymus Gland/*immunology
Animals ; Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; Cell Aggregation ; Cell Differentiation ; Cholesterol Side-Chain Cleavage Enzyme/genetics ; Embryo, Mammalian/immunology ; Histocompatibility Antigens Class II ; Lectins, C-Type ; Mice ; Mice, Inbred BALB C ; Organ Culture Techniques ; RNA, Messenger/biosynthesis ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Stromal Cells ; Thymus Gland/cytology ; Thymus Gland/embryology
Grant Information :
United Kingdom Wellcome Trust
Substance Nomenclature :
0 (Antigens, CD)
0 (Antigens, Differentiation, T-Lymphocyte)
0 (CD69 antigen)
0 (Glucocorticoids)
0 (Histocompatibility Antigens Class II)
0 (Lectins, C-Type)
0 (RNA, Messenger)
0 (Receptors, Antigen, T-Cell)
EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme)
Entry Date(s) :
Date Created: 19991126 Date Completed: 19991220 Latest Revision: 20181130
Update Code :
20210210
PMID :
10570260
Czasopismo naukowe
Thymic epithelial cells are uniquely efficient in mediating positive selection, suggesting that in addition to providing peptide/MHC complexes for TCR ligation, they may also provide additional support for this process. Recent studies have shown that although engagement of either the TCR or glucocorticoid (GC) receptors can individually induce apoptosis in thymocytes, together these signals are mutually antagonistic. This had led to the suggestion that local GC production by thymic epithelial cells, by opposing TCR signaling for apoptosis, provides the basis of the ability of these cells to mediate thymocyte positive selection. In this paper we have examined this possibility directly and shown that highly purified cortical epithelial cells, which have the functional ability to mediate positive selection in reaggregate cultures, do not express mRNA for the key steroidogenic enzyme P405scc. Thus we conclude that the ability of thymic epithelial cells to support positive selection does not rely on their ability to produce GC. However, we find that P450scc mRNA is up-regulated in thymocytes on the initiation of positive selection, raising the possibility that any local protective effect of steroid production is mediated at the level of thymocytes themselves.

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