[Modulation of human peripheral blood neutrophil apoptosis by ultraviolet C-range radiation and by gamma-irradiation].

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Abstrakt

Tytuł:: [Modulation of human peripheral blood neutrophil apoptosis by ultraviolet C-range radiation and by gamma-irradiation].
Autorzy:: Vinokurov MG; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Kosiakova NI
Nikolaeva NN
Pechatnikov VA
Transliterated Title:: Moduliatsiia apoptoza neĭtrofilov perifericheskoĭ krovi cheloveka ul'trafioletovym izlucheniem diapazona C i gamma-izlucheniem.
Źródło:: Biofizika [Biofizika] 1999 Sep-Oct; Vol. 44 (5), pp. 929-30.
Typ publikacji:: English Abstract; Journal Article
Język:: Russian
Imprint Name(s):: Original Publication: Moskva : Izdatelstvo Nauka
MeSH Terms:: Apoptosis/*radiation effects
Neutrophils/*radiation effects
Apoptosis/drug effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Humans ; In Vitro Techniques ; Lipopolysaccharides/pharmacology ; Neutrophils/cytology ; Ultraviolet Rays
Substance Nomenclature:: 0 (Lipopolysaccharides)
Entry Date(s):: Date Created: 20000107 Date Completed: 20000204 Latest Revision: 20141120
Update Code:: 20240104
PMID:: 10624538
: Czasopismo naukowe

It was found that the irradiation with in vitro UVC (254 nm) in the dose range of 6-600 J/m2 accelerates the apoptosis of human peripheral blood neutrophils in a dose-dependent manner, with saturation occurring at UVC doses of 250-300 J/m2. gamma-Irradiation with a dose of 2 Gy accelerates the apoptosis of neutrophils, whereas the irradiation with doses of 10 and 20 Gy suppresses it (by 9 h of cultivation). Lipopolysaccharide (1 microgram/ml) suppresses the UVC-induced apoptosis of neutrophils.

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