Reproducibility of magnetization transfer ratio histogram-derived measures of the brain in healthy volunteers.

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Abstract

Title:: Reproducibility of magnetization transfer ratio histogram-derived measures of the brain in healthy volunteers.
Authors:: Sormani MP; Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
Iannucci G
Rocca MA
Mastronardo G
Cercignani M
Minicucci L
Filippi M
Source:: AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2000 Jan; Vol. 21 (1), pp. 133-6.
Publication Type:: Journal Article; Research Support, Non-U.S. Gov't
Language:: English
Imprint Name(s):: Publication: Oak Brook, IL : American Society of Neuroradiology
Original Publication: Baltimore, Williams & Wilkins.
MeSH Terms:: Magnetic Resonance Imaging*
Brain/*anatomy & histology
Adult ; Female ; Humans ; Male ; Observer Variation ; Reference Values ; Reproducibility of Results
References:: Magn Reson Med. 1996 Oct;36(4):632-6. (PMID: 8892218)
Eur Neurol. 1999;41(4):226-30. (PMID: 10343154)
J Neurol Neurosurg Psychiatry. 1998 May;64 Suppl 1:S52-8. (PMID: 9647286)
AJNR Am J Neuroradiol. 1995 Feb;16(2):225-31. (PMID: 7726066)
Neurology. 1999 Feb;52(3):588-94. (PMID: 10025793)
J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):683-8. (PMID: 1940938)
Neurology. 1998 Jun;50(6):1601-8. (PMID: 9633700)
Neurology. 1997 Aug;49(2):371-7. (PMID: 9270564)
J Comput Assist Tomogr. 1996 Jul-Aug;20(4):540-6. (PMID: 8708052)
AJNR Am J Neuroradiol. 1994 Feb;15(2):201-12. (PMID: 8192062)
Med Phys. 1984 Jul-Aug;11(4):425-48. (PMID: 6482839)
Entry Date(s):: Date Created: 20000211 Date Completed: 20000301 Latest Revision: 20210605
Update Code:: 20240104
PubMed Central ID:: PMC7976350
PMID:: 10669238
: Academic Journal

Using two MR scanners, we evaluated the intraobserver, interobserver, image-reimage, and interimager variabilities in the assessment of magnetization transfer ratio (MTR) histograms obtained monthly on four occasions from five healthy volunteers. With multiple observers, the mean coefficients of variations ranged from 2.2% to 8.2% for "pure" image-reimage variability, from 1.2% to 4.9% for interobserver variability, and from 2.1% to 4.9% for image-reimage variability. The mean intraobserver coefficients of variations were always lower than 1%. The mean coefficients of variations ranged from 10.2% to 14.6% for pure interimager variability and from 8.6% to 14.3% for interimager variability with multiple observers. Interimager variability accounted for 96.0% of the overall variability of average MTR, for 96.7% of peak location, and for 41.1% of the peak height. The use of different MR scanners is the main source of variability when obtaining MTR histograms.

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