The stem of sinomenium acutum inhibits mast cell-mediated anaphylactic reactions and tumor necrosis factor-alpha production from rat peritoneal mast cells.

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Abstrakt

Tytuł:: The stem of sinomenium acutum inhibits mast cell-mediated anaphylactic reactions and tumor necrosis factor-alpha production from rat peritoneal mast cells.
Autorzy:: Kim HM; Department of Oriental Pharmacy, College of Pharmacy and Center of Oriental Medicinal Science, Wonkwang University, Iksan, Chonbuk, South Korea. />Moon PD
Chae HJ
Kim HR
Chung JG
Kim JJ
Lee EJ
Źródło:: Journal of ethnopharmacology [J Ethnopharmacol] 2000 May; Vol. 70 (2), pp. 135-41.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Limerick : Elsevier Sequoia
Original Publication: Lausanne, Elsevier Sequoia.
MeSH Terms:: Plants, Medicinal*
Anaphylaxis/*prevention & control
Mast Cells/*drug effects
Tumor Necrosis Factor-alpha/*antagonists & inhibitors
Animals ; Histamine Release/drug effects ; Immunoglobulin E/immunology ; Korea ; Male ; Mast Cells/physiology ; Mice ; Mice, Inbred BALB C ; Peritoneum/cytology ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha/biosynthesis ; p-Methoxy-N-methylphenethylamine/pharmacology
Substance Nomenclature:: 0 (Tumor Necrosis Factor-alpha)
37341-29-0 (Immunoglobulin E)
4091-50-3 (p-Methoxy-N-methylphenethylamine)
Entry Date(s):: Date Created: 20000420 Date Completed: 20000901 Latest Revision: 20190831
Update Code:: 20240104
DOI:: 10.1016/s0378-8741(99)00160-9
PMID:: 10771203
: Czasopismo naukowe

The aqueous extract of Sinomenium acutum stem (SSAE) (0.1-1000 mg/kg) dose-dependently inhibited systemic anaphylactic reaction induced by compound 48/80 in mice. In particular, SSAE reduced compound 48/80-induced anaphylactic reaction with 50% at the dose of 1000 mg/kg. SSAE (100-1000 mg/kg) also significantly inhibited local anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. When mice were pretreated with SSAE at a concentration ranging from 0.1 to 1000 mg/kg, the plasma histamine levels were reduced in a dose-dependent manner. SSAE (1-1000 microg/ml) dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMCs) activated by compound 48/80 or anti-DNP IgE. In addition, SSAE (0.1 microg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha (TNF-alpha) production. These results indicate that SSAE inhibits mast cell-mediated anaphylactic reactions and TNF-alpha production from mast cells.

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