Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors.

Szczegóły
Abstrakt

Tytuł:: Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors.
Autorzy:: Sacktor NC; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
Skolasky RL
Lyles RH
Esposito D
Selnes OA
McArthur JC
Źródło:: Journal of neurovirology [J Neurovirol] 2000 Feb; Vol. 6 (1), pp. 84-8.
Typ publikacji:: Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Język:: English
Imprint Name(s):: Publication: 2011- : New York : Springer
Original Publication: Houndmills, Basingstoke, Hampshire ; New York, NY : Stockton Press, c1995-
MeSH Terms:: AIDS Dementia Complex/*drug therapy
Acquired Immunodeficiency Syndrome/*drug therapy
Anti-HIV Agents/*therapeutic use
HIV Protease Inhibitors/*therapeutic use
Movement Disorders/*drug therapy
AIDS Dementia Complex/virology ; Acquired Immunodeficiency Syndrome/complications ; Adult ; Female ; Functional Laterality ; HIV Seropositivity ; Hand/physiopathology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Movement Disorders/etiology ; Neuropsychological Tests ; Prospective Studies ; Psychomotor Performance/drug effects ; Viral Load
Grant Information:: NS 26643 United States NS NINDS NIH HHS; RR00722 United States RR NCRR NIH HHS
Substance Nomenclature:: 0 (Anti-HIV Agents)
0 (HIV Protease Inhibitors)
Entry Date(s):: Date Created: 20000429 Date Completed: 20000609 Latest Revision: 20191103
Update Code:: 20240104
DOI:: 10.3109/13550280009006385
PMID:: 10787000
: Czasopismo naukowe

A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test after initiating HAART (P=0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P=0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.

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