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Tytuł:
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Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by gender.
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Autorzy:
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Bullido MJ; Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Cantoblanco, Madrid, Spain.
Guallar-Castillón P
Artiga MJ
Ramos MC
Sastre I
Aldudo J
Frank A
Coria F
Rodríguez-Artalejo F
Valdivieso F
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Źródło:
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Neuroscience letters [Neurosci Lett] 2000 Aug 11; Vol. 289 (3), pp. 213-6.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
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MeSH Terms:
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Alzheimer Disease/*genetics
Apolipoproteins E/*genetics
Polymorphism, Genetic/*genetics
alpha-Macroglobulins/*genetics
Age Factors ; Aged ; Female ; Genotype ; Humans ; Low Density Lipoprotein Receptor-Related Protein-1 ; Male ; Promoter Regions, Genetic/genetics ; Receptors, Immunologic/genetics ; Risk Factors ; Sex Factors
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Substance Nomenclature:
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0 (Apolipoproteins E)
0 (Low Density Lipoprotein Receptor-Related Protein-1)
0 (Receptors, Immunologic)
0 (alpha-Macroglobulins)
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Entry Date(s):
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Date Created: 20000829 Date Completed: 20010531 Latest Revision: 20190701
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Update Code:
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20240104
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DOI:
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10.1016/s0304-3940(00)01304-5
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PMID:
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10961667
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Apolipoprotein E (apoE), the lipoprotein receptor related protein (LRP) and alpha-2 macroglobulin (alpha2M) have been proposed as a functional complex involved in amyloid clearance, a crucial event for Alzheimer's disease development. In this work, we present an epidemiological approach aimed to study the interactions among these genes, age and gender. This approach did not reveal significant associations between the genes; however, the present study indicated that the risk associated with APOE promoter and LRP gene polymorphisms is modulated by gender.