The impact of peak saturation of the arterial input function on quantitative evaluation of dynamic susceptibility contrast-enhanced MR studies.

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Abstrakt

Tytuł:: The impact of peak saturation of the arterial input function on quantitative evaluation of dynamic susceptibility contrast-enhanced MR studies.
Autorzy:: Ellinger R; Department of Magnetic Resonance, University of Innsbruck, Austria.
Kremser C
Schocke MF
Kolbitsch C
Griebel J
Felber SR
Aichner FT
Źródło:: Journal of computer assisted tomography [J Comput Assist Tomogr] 2000 Nov-Dec; Vol. 24 (6), pp. 942-8.
Typ publikacji:: Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2000->: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, Raven Press.
MeSH Terms:: Contrast Media*
Brain/*blood supply
Cerebrovascular Circulation/*physiology
Image Enhancement/*methods
Magnetic Resonance Imaging/*methods
Adult ; Algorithms ; Arteries/anatomy & histology ; Artifacts ; Blood Volume/physiology ; Computer Simulation ; Echo-Planar Imaging/methods ; Gadolinium DTPA ; Humans ; Male ; Models, Cardiovascular ; Time Factors ; Tomography, Emission-Computed
Substance Nomenclature:: 0 (Contrast Media)
K2I13DR72L (Gadolinium DTPA)
Entry Date(s):: Date Created: 20001206 Date Completed: 20001222 Latest Revision: 20220408
Update Code:: 20240104
DOI:: 10.1097/00004728-200011000-00022
PMID:: 11105716
: Czasopismo naukowe

Purpose: The purpose of this work was to investigate systematic errors in dynamic contrast-enhanced MR perfusion studies due to peak saturation of the arterial input function (AIF) and to introduce a simple correction algorithm.
Method: Computer simulations were performed to evaluate the influence of AIF peak saturation and to demonstrate the effectiveness of the presented correction algorithm. To compare the computer simulations with real MR data, MR perfusion measurements were performed on volunteers.
Results: The computer simulations show that AIF peak saturation leads to a systematic overestimation of cerebral blood volume (CBV) and cerebral blood flow (CBF) values, which was confirmed by comparing the obtained MR data with PET results. With use of an improved calculation algorithm correcting for AIF peak saturation, a significant improvement of the obtained CBV and CBF values could be demonstrated.
Conclusion: Our results suggest that AIF peak saturation leads to a significant systematic error in the determination of CBV and CBF values and has necessarily to be taken into account for dynamic contrast-enhanced MR perfusion studies.

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