Activation of expression of hedgehog target genes in basal cell carcinomas.

Szczegóły
Abstrakt

Tytuł:: Activation of expression of hedgehog target genes in basal cell carcinomas.
Autorzy:: Bonifas JM; Department of Dermatology, San Francisco General Hospital, California, USA.
Pennypacker S
Chuang PT
McMahon AP
Williams M
Rosenthal A
De Sauvage FJ
Epstein EH Jr
Źródło:: The Journal of investigative dermatology [J Invest Dermatol] 2001 May; Vol. 116 (5), pp. 739-42.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Język:: English
Imprint Name(s):: Publication: 2016- : New York : Elsevier
Original Publication: Baltimore, Williams & Wilkins.
MeSH Terms:: Gene Expression*
Trans-Activators*
Zebrafish Proteins*
Carcinoma, Basal Cell/*genetics
Proteins/*genetics
Skin Neoplasms/*genetics
Carcinoma, Basal Cell/metabolism ; Cell Line ; Hedgehog Proteins ; Hemidesmosomes/metabolism ; Humans ; Kruppel-Like Transcription Factors ; Membrane Proteins/genetics ; Nuclear Proteins ; Oncogene Proteins/genetics ; Patched Receptors ; Patched-1 Receptor ; Protein Isoforms/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Messenger/metabolism ; Receptors, Cell Surface ; Reference Values ; Skin/metabolism ; Skin Neoplasms/metabolism ; Transcription Factors/genetics ; Wnt Proteins ; Zinc Finger Protein GLI1 ; Zinc Finger Protein Gli2
Grant Information:: AR39448 United States AR NIAMS NIH HHS; AR39959 United States AR NIAMS NIH HHS; CA81888 United States CA NCI NIH HHS; NS33642 United States NS NINDS NIH HHS
Substance Nomenclature:: 0 (GLI2 protein, human)
0 (Hedgehog Proteins)
0 (Kruppel-Like Transcription Factors)
0 (Membrane Proteins)
0 (Nuclear Proteins)
0 (Oncogene Proteins)
0 (Patched Receptors)
0 (Patched-1 Receptor)
0 (Protein Isoforms)
0 (Proteins)
0 (Proto-Oncogene Proteins)
0 (Proto-Oncogene Proteins c-myc)
0 (RNA, Messenger)
0 (Receptors, Cell Surface)
0 (Trans-Activators)
0 (Transcription Factors)
0 (Wnt Proteins)
0 (Zebrafish Proteins)
0 (Zinc Finger Protein GLI1)
0 (Zinc Finger Protein Gli2)
0 (ptch1 protein, zebrafish)
Entry Date(s):: Date Created: 20010512 Date Completed: 20010705 Latest Revision: 20190422
Update Code:: 20240104
DOI:: 10.1046/j.1523-1747.2001.01315.x
PMID:: 11348463
: Czasopismo naukowe

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Mutations in hedgehog signaling pathway genes, especially PTC1 and SMO, are pivotal to the development of basal cell carcinomas. The study of basal cell carcinoma gene expression not only may elucidate mechanisms by which hedgehog signaling abnormalities produce aberrant tumor cell behavior but also can provide data on in vivo hedgehog target gene control in humans. We have found, in comparison with normal skin, that basal cell carcinomas have increased levels of mRNA for PTC1, GLI1, HIP, WNT2B, and WNT5a; decreased levels of mRNA for c-MYC, c-FOS, and WNT4; and unchanged levels of mRNA for PTC2, GLI2, WNT7B, and BMP2 and 4. These findings suggest that mutations in hedgehog signaling pathway genes may exert both cell autonomous and indirect effects and indicate that basal cell carcinoma tumor cells have a phenotype that at least in some aspects resembles that of epidermal stem cells.

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