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Tytuł:
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Observer variation in contouring gross tumor volume in patients with poorly defined non-small-cell lung tumors on CT: the impact of 18FDG-hybrid PET fusion.
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Autorzy:
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Caldwell CB; Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada. />Mah K
Ung YC
Danjoux CE
Balogh JM
Ganguli SN
Ehrlich LE
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Źródło:
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International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2001 Nov 15; Vol. 51 (4), pp. 923-31.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: New York, NY : Elsevier, Inc
Original Publication: Elmsford, N. Y., Pergamon Press.
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MeSH Terms:
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Fluorodeoxyglucose F18*
Radiopharmaceuticals*
Carcinoma, Non-Small-Cell Lung/*diagnostic imaging
Lung Neoplasms/*diagnostic imaging
Tomography, Emission-Computed/*methods
Tomography, X-Ray Computed/*methods
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/secondary ; Female ; Humans ; Lymphatic Metastasis/diagnostic imaging ; Male ; Neoplasm Staging ; Observer Variation ; Prospective Studies
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Substance Nomenclature:
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0 (Radiopharmaceuticals)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
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Entry Date(s):
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Date Created: 20011113 Date Completed: 20011213 Latest Revision: 20220410
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Update Code:
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20240104
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DOI:
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10.1016/s0360-3016(01)01722-9
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PMID:
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11704312
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Purpose: To quantify interobserver variation in gross tumor volume (GTV) localization using CT images for patients with non-small-cell lung carcinoma and poorly defined tumors on CT and to determine whether variability would be reduced if coregistered 2-[18F]fluoro-2-deoxy-d-glucose (FDG)-hybrid positron emission tomography (PET) with CT images were used.
Methods and Materials: Prospectively, 30 patients with non-small-cell lung carcinoma had CT and FDG-hybrid PET examinations in radiation treatment position on the same day. Images were coregistered using eight fiducial markers. Guidelines were established for contouring GTVs. Three radiation oncologists performed localization independently. The coefficient of variation was used to assess interobserver variability.
Results: The size of the GTV defined showed great variation among observers. The mean ratios of largest to smallest GTV were 2.31 and 1.56 for CT only and for CT/FDG coregistered data, respectively. The addition of PET reduced this ratio in 23 of 30 cases and increased it in 7. The mean coefficient of variation for GTV based on the combined modalities was significantly smaller (p < 0.01) than that for CT data only.
Conclusions: High observer variability in CT-based definition of the GTV can occur. A more consistent definition of the GTV can often be obtained if coregistered FDG-hybrid PET images are used.
