Effects of thyroid hormones on inner mitochondrial membrane fluidity.

Szczegóły
Abstrakt

Tytuł:: Effects of thyroid hormones on inner mitochondrial membrane fluidity.
Autorzy:: Chimenti R; Department of Cell Biology, University of Calabria, Rende.
Covello C
De Cicco T
Bruno R
Martino G
Źródło:: Bollettino della Societa italiana di biologia sperimentale [Boll Soc Ital Biol Sper] 2001 Apr-Jun; Vol. 77 (4-6), pp. 21-6.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2014- : Pavia, Italy : PAGEPress
Original Publication: Napoli, Società italiana di biologia sperimentale.
MeSH Terms:: Diiodothyronines/*metabolism
Membrane Fluidity/*physiology
Mitochondria/*physiology
Thyroxine/*metabolism
Triiodothyronine/*metabolism
Animals ; Diiodothyronines/pharmacology ; Intracellular Membranes/drug effects ; Male ; Membrane Fluidity/drug effects ; Mitochondria/drug effects ; Rats ; Rats, Wistar ; Thyroxine/pharmacology ; Triiodothyronine/pharmacology
Substance Nomenclature:: 0 (Diiodothyronines)
06LU7C9H1V (Triiodothyronine)
Q51BO43MG4 (Thyroxine)
Entry Date(s):: Date Created: 20020202 Date Completed: 20020219 Latest Revision: 20131121
Update Code:: 20240104
PMID:: 11822198
: Czasopismo naukowe

Authors studied the effects of thyroid hormones and their diasteroisomers and 3,5-diiodothyronine (LT2) on the fluidity properties of inner mitochondrial membrane (IMM) by specifical fluorescent probe for the internal zone of biological membranes, the 1,6-diphenyl-1,3,5-hexatriene (DPH). The studied parameters are Arrhenius and Perrin plots. The DPH shows a decreased fluorescence quenching in the presence of both T3 and T4. The maximum effect is observed with 2 nM LT2. LT2 is more effective than LT3 in the central zone. The data confirm the selective action of LT3 and LT4 on IMM fluidity.

Informacja