Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome.

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Abstrakt

Tytuł:: Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome.
Autorzy:: Ang CW; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. />Tio-Gillen AP
Groen J
Herbrink P
Jacobs BC
Van Koningsveld R
Osterhaus AD
Van der Meché FG
van Doorn PA
Źródło:: Journal of neuroimmunology [J Neuroimmunol] 2002 Sep; Vol. 130 (1-2), pp. 179-83.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981-
MeSH Terms:: Autoantibodies/*immunology
Galactosylceramides/*immunology
Guillain-Barre Syndrome/*immunology
Guillain-Barre Syndrome/*microbiology
Molecular Mimicry/*immunology
Mycoplasma Infections/*immunology
Mycoplasma pneumoniae/*immunology
Autoantibodies/blood ; Cross Reactions/immunology ; Guillain-Barre Syndrome/blood ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Mycoplasma Infections/blood ; Mycoplasma Infections/diagnosis ; Mycoplasma pneumoniae/pathogenicity
Substance Nomenclature:: 0 (Autoantibodies)
0 (Galactosylceramides)
0 (Immunoglobulin G)
0 (Immunoglobulin M)
Entry Date(s):: Date Created: 20020913 Date Completed: 20021104 Latest Revision: 20190826
Update Code:: 20240104
DOI:: 10.1016/s0165-5728(02)00209-6
PMID:: 12225900
: Czasopismo naukowe

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Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.

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