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Tytuł pozycji:

The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers.

Tytuł:
The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers.
Autorzy:
Kolbitsch C; Department of Anaesthesia and Intensive Care Medicine, University of Innsbruck, Innsbruck, Austria. />Lorenz IH
Hörmann C
Hinteregger M
Löckinger A
Moser PL
Kremser C
Schocke M
Felber S
Pfeiffer KP
Benzer A
Źródło:
Magnetic resonance imaging [Magn Reson Imaging] 2002 Sep; Vol. 20 (7), pp. 535-41.
Typ publikacji:
Comparative Study; Journal Article
Język:
English
Imprint Name(s):
Publication: <2008->: Amsterdam : Elsevier
Original Publication: New York : Pergamon, c1982-
MeSH Terms:
Echo-Planar Imaging*
Hyperoxia*
Ultrasonography, Doppler, Transcranial*
Middle Cerebral Artery/*physiology
Adult ; Blood Flow Velocity ; Blood Volume ; Contrast Media ; Humans ; Male ; Statistics, Nonparametric
Substance Nomenclature:
0 (Contrast Media)
Entry Date(s):
Date Created: 20021105 Date Completed: 20030313 Latest Revision: 20190906
Update Code:
20240104
DOI:
10.1016/s0730-725x(02)00534-9
PMID:
12413599
Czasopismo naukowe
Conflicting results reported on the effects of hyperoxia on cerebral hemodynamics have been attributed mainly to methodical and species differences. In the present study contrast-enhanced magnetic resonance imaging (MRI) perfusion measurement was used to analyze the influence of hyperoxia (fraction of inspired oxygen (FiO2) = 1.0) on regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in awake, normoventilating volunteers (n = 19). Furthermore, the experiment was repeated in 20 volunteers for transcranial Doppler sonography (TCD) measurement of cerebral blood flow velocity in the middle cerebral artery (CBFV(MCA)). When compared to normoxia (FiO2 = 0.21), hyperoxia heterogeneously influenced rCBV (4.95 +/- 0.02 to 12.87 +/- 0.08 mL/100g (FiO2 = 0.21) vs. 4.50 +/- 0.02 to 13.09 +/- 0.09 mL/100g (FiO2 = 1.0). In contrast, hyperoxia diminished rCBF in all regions (68.08 +/- 0.38 to 199.58 +/- 1.58 mL/100g/min (FiO2 = 0.21) vs. 58.63 +/- 0.32 to 175.16 +/- 1.51 mL/100g/min (FiO2 = 1.0)) except in parietal and left frontal gray matter. CBFV(MCA) remained unchanged regardless of the inspired oxygen fraction (62 +/- 9 cm/s (FiO2 = 0.21) vs. 64 +/- 8 cm/s (FiO2 = 1.0)). Finding CBFV(MCA) unchanged during hyperoxia is consistent with the present study's unchanged rCBF in parietal and left frontal gray matter. In these fronto-parietal regions predominantly fed by the middle cerebral artery, the vasoconstrictor effect of oxygen was probably counteracted by increased perfusion of foci of neuronal activity controlling general behavior and arousal.

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