Gene expression of cell surface antigens in the early phase of murine influenza pneumonia determined by a cDNA expression array technique.

Szczegóły
Abstrakt

Tytuł:: Gene expression of cell surface antigens in the early phase of murine influenza pneumonia determined by a cDNA expression array technique.
Autorzy:: Sakai S; Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. />Mantani N
Kogure T
Ochiai H
Shimada Y
Terasawa K
Źródło:: Mediators of inflammation [Mediators Inflamm] 2002 Dec; Vol. 11 (6), pp. 359-61.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-
MeSH Terms:: Gene Expression*
Orthomyxoviridae Infections*
Antigens, Surface/*genetics
Pneumonia/*immunology
Pneumonia/*microbiology
Adenosine Triphosphatases/genetics ; Animals ; Antigens, CD/genetics ; Antigens, CD1/genetics ; Antigens, CD1d ; Antigens, Differentiation, Myelomonocytic/genetics ; Apyrase ; Chick Embryo ; Down-Regulation ; Female ; Mice ; Mice, Inbred ICR ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/metabolism ; Up-Regulation
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Substance Nomenclature:: 0 (Antigens, CD)
0 (Antigens, CD1)
0 (Antigens, CD1d)
0 (Antigens, Differentiation, Myelomonocytic)
0 (Antigens, Surface)
0 (CD68 antigen, human)
0 (RNA, Messenger)
EC 3.6.1.- (Adenosine Triphosphatases)
EC 3.6.1.5 (Apyrase)
EC 3.6.1.5 (CD39 antigen)
Entry Date(s):: Date Created: 20030213 Date Completed: 20030613 Latest Revision: 20181113
Update Code:: 20240104
PubMed Central ID:: PMC1781684
DOI:: 10.1080/0962935021000051557
PMID:: 12581500
: Czasopismo naukowe

Pełny tekst

Background: Influenza virus is a worldwide health problem with significant economic consequences. To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study.
Aims: To assess the influence of influenza virus infection on gene expression in mice, mRNA levels in the lung and tracheal tissue 48 h after infection were investigated by cDNA array analysis.
Methods: Four-week-old outbred, specific pathogen free strain, ICR female mice were infected by intra-nasal inoculation of a virus solution under ether anesthesia. The mice were sacrificed 48 h after infection and the tracheas and lungs were removed. To determine gene expression, the membrane-based microtechnique with an Atlas cDNA expression array (mouse 1.2 array II) was performed in accordance with the manual provided.
Results and Conclusions: We focused on the expression of 46 mRNAs for cell surface antigens. Of these 46 mRNAs that we examined, four (CD1d2 antigen, CD39 antigen-like 1, CD39 antigen-like 3, CD68 antigen) were up-regulated and one (CD36 antigen) was down-regulated. Although further studies are required, these data suggest that these molecules play an important role in influenza virus infection, especially the phase before specific immunity.

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