Natural killer (NK) cell receptors' repertoire in couples with recurrent spontaneous abortions.

Szczegóły
Abstrakt

Tytuł:: Natural killer (NK) cell receptors' repertoire in couples with recurrent spontaneous abortions.
Autorzy:: Varla-Leftherioti M; Immunology Department and RSA Clinic, Helena Venizelou Maternity Hospital, Athens, Greece. />Spyropoulou-Vlachou M
Niokou D
Keramitsoglou T
Darlamitsou A
Tsekoura C
Papadimitropoulos M
Lepage V
Balafoutas C
Stavropoulos-Giokas C
Źródło:: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2003 Mar; Vol. 49 (3), pp. 183-91.
Typ publikacji:: Comparative Study; Journal Article
Język:: English
Imprint Name(s):: Publication: Copenhagen : Wiley-Blackwell
Original Publication: New York : Alan R. Liss, Inc., c1989-
MeSH Terms:: Abortion, Habitual/*immunology
Killer Cells, Natural/*metabolism
Receptors, Immunologic/*genetics
Abortion, Habitual/blood ; Abortion, Habitual/genetics ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Family Characteristics ; Female ; Genotype ; HLA Antigens/genetics ; HLA Antigens/metabolism ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Male ; NK Cell Lectin-Like Receptor Subfamily C ; NK Cell Lectin-Like Receptor Subfamily D ; Polymerase Chain Reaction/methods ; Pregnancy ; Receptors, Immunologic/metabolism ; Receptors, KIR ; Receptors, KIR2DL1 ; Receptors, Natural Killer Cell ; Trophoblasts/immunology ; Trophoblasts/metabolism
Substance Nomenclature:: 0 (Antigens, CD)
0 (HLA Antigens)
0 (Histocompatibility Antigens Class I)
0 (KLRC1 protein, human)
0 (KLRC2 protein, human)
0 (KLRD1 protein, human)
0 (Lectins, C-Type)
0 (NK Cell Lectin-Like Receptor Subfamily C)
0 (NK Cell Lectin-Like Receptor Subfamily D)
0 (Receptors, Immunologic)
0 (Receptors, KIR)
0 (Receptors, KIR2DL1)
0 (Receptors, Natural Killer Cell)
Entry Date(s):: Date Created: 20030612 Date Completed: 20031010 Latest Revision: 20190922
Update Code:: 20240104
DOI:: 10.1034/j.1600-0897.2003.00018.x
PMID:: 12797525
: Czasopismo naukowe

Pełny tekst

Problem: Natural killer (NK) cell receptors (NKRs) have been suggested to protect trophoblast, but their function at the fetomaternal interface remains unknown. To investigate if the outcome of pregnancy depends on women's NKRs, we studied the NKR repertoire in couples with recurrent spontaneous abortions (RSA).
Methods: Twenty-six childless couples with > or = 2 abortions, characterized by alloimmune abnormalities, and 26 control couples were genotyped for five killer immunoglobulin-like receptors (KIR) and two CD94/NKG receptors, known to have as ligands human leukocyte antigen (HLA) class I molecules with trophoblastic expression: inhibitory 2DL1,2,3 and activating 2DS1,4 KIRs, inhibitory NKG2A and activating NKG2C. Detected repertoires of women and partners were compared between the two groups.
Results: Less aborters than controls were found to have all three inhibitory KIRs (30.77% versus 69.23%, P = 0.01), some of them had only one inhibitory KIR (19.23% versus 3.85%, P = 0.08) and most of them were lacking inhibitory KIRs possessed by their husbands (57.69% versus 15.38%, P = 0.001).
Conclusions: Women with alloimmune abortions have a limited inhibiting KIR repertoire and such miscarriages may occur because trophoblastic HLA class I molecules are recognized by decidual NK cells lacking the appropriate inhibitory KIRs.

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