Role of NK-2 receptors in the antidipsogenic activity of neurokinins in the mouse.

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Abstrakt

Tytuł:: Role of NK-2 receptors in the antidipsogenic activity of neurokinins in the mouse.
Autorzy:: Walsh DM; Neuropharmacology Department, Glaxo Group Research Ltd, Ware, England.
Elliott PJ
Hagan RM
Źródło:: General pharmacology [Gen Pharmacol] 1992 Mar; Vol. 23 (2), pp. 231-3.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Exeter : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
MeSH Terms:: Drinking/*drug effects
Kinins/*pharmacology
Receptors, Neurotransmitter/*physiology
Animals ; Injections, Intraventricular ; Kinins/administration & dosage ; Male ; Mice ; Mice, Inbred Strains ; Receptors, Neurokinin-2 ; Receptors, Neurotransmitter/antagonists & inhibitors ; Water Deprivation
Substance Nomenclature:: 0 (Kinins)
0 (Receptors, Neurokinin-2)
0 (Receptors, Neurotransmitter)
Entry Date(s):: Date Created: 19920301 Date Completed: 19920903 Latest Revision: 20190824
Update Code:: 20240104
DOI:: 10.1016/0306-3623(92)90016-d
PMID:: 1322337
: Czasopismo naukowe

1. The receptors involved in the anti-dipsogenic activity of neurokinin (NK) agonists were investigated in water-deprived mice. 2. Intracerebral administration of agonists selective at all three NK receptors (NK-1, NK-2, NK-3) caused inhibition of drinking in this model. However, only the NK-2 receptor agonist, GR64349, inhibited drinking without producing other behavioural effects. Both NK-1 (GR73632) and NK-3 (senktide) agonists induced a variety of behavioural effects which appeared to compete with the drinking response. 3. The inhibitory effect on drinking observed after central injection of the NK-2 agonist, GR64349, was attenuated by co-administration of the NK-2 antagonist, L-659,877, but not by the NK-1 antagonist, GR82334. 4. These results illustrate that the antidipsogenic activity of the NKs, in mice, is mediated via NK-2 receptors.

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