Quinine intoxications reported to the Scottish Poisons Information Bureau 1997-2002: a continuing problem.

Tytuł:: Quinine intoxications reported to the Scottish Poisons Information Bureau 1997-2002: a continuing problem.
Autorzy:: Langford NJ; West Midlands Centre for Adverse Drug Reaction Reporting, City Hospital, Birmingham, UK. />Good AM
Laing WJ
Bateman DN
Źródło:: British journal of clinical pharmacology [Br J Clin Pharmacol] 2003 Nov; Vol. 56 (5), pp. 576-8.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Oxford : Wiley-Blackwell
Original Publication: London, Macmillan Journals Ltd.
MeSH Terms:: Muscle Relaxants, Central/*poisoning
Quinine/*poisoning
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Drug Overdose/epidemiology ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Muscle Cramp/drug therapy ; Muscle Cramp/epidemiology ; Scotland/epidemiology
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Substance Nomenclature:: 0 (Muscle Relaxants, Central)
A7V27PHC7A (Quinine)
Entry Date(s):: Date Created: 20031204 Date Completed: 20040202 Latest Revision: 20231105
Update Code:: 20240104
PubMed Central ID:: PMC1884390
DOI:: 10.1046/j.1365-2125.2003.01921.x
PMID:: 14651733
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Quinine is widely prescribed in the UK for night cramps. Its potential toxicity in overdose is well known. We have reviewed the Scottish experience of enquiries regarding quinine overdose to the poisons information service responsible for Scotland over a 6-year period. Between 1997 and 2002 there were 96 reports of suspected quinine toxicity from Scotland (population 5.2 million), 19 of which were in children. The largest quantities of drug ingested were in patients between the ages of 11 and 30. In comparison with older studies the pattern of quinine poisoning does not appear to have changed in the UK over 20 years, despite recognition that it is a toxic agent in overdose, and particularly in children.

Comment in: Br J Clin Pharmacol. 2004 Jun;57(6):817; author reply 817. (PMID: 15151529)

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