Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana.

Szczegóły
Abstrakt

Tytuł:: Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana.
Autorzy:: Costa-Lotufo LV; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Silveira ER
Barros MC
Lima MA
De Moraes ME
De Moraes MO
Pessoa C
Źródło:: Planta medica [Planta Med] 2004 Feb; Vol. 70 (2), pp. 180-2.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Stuttgart ; New York : George Thieme
Original Publication: Stuttgart, Hippokrates Verlag.
MeSH Terms:: Phytotherapy*
Verbenaceae*
Abietanes/*pharmacology
Antineoplastic Agents, Phytogenic/*pharmacology
Plant Extracts/*pharmacology
Abietanes/administration & dosage ; Abietanes/therapeutic use ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor/drug effects ; Erythrocytes/drug effects ; Humans ; Inhibitory Concentration 50 ; Mice ; Mitosis/drug effects ; Ovum/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/therapeutic use ; Plant Roots ; Sea Urchins
Substance Nomenclature:: 0 (Abietanes)
0 (Antineoplastic Agents, Phytogenic)
0 (Plant Extracts)
Entry Date(s):: Date Created: 20040303 Date Completed: 20040406 Latest Revision: 20191210
Update Code:: 20240104
DOI:: 10.1055/s-2004-815499
PMID:: 14994200
: Czasopismo naukowe

Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been described for this species. These compounds were tested for their antiproliferative effects on tumor cell lines using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl- 2H-tetrazolium bromide (MTT) assay and on sea urchin egg development, as well as for their lytic properties on mouse erythrocytes. All diterpenes reduced the viability of tumor cells and inhibited sea urchin egg cleavage. None of the tested compounds presented hemolytic activity.

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