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Tytuł:
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Tissue-engineered skin substitutes: from in vitro constructs to in vivo applications.
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Autorzy:
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Auger FA; Laboratoire d'Organogénèse Expérimentale/LOEX, Saint-Sacrement Hospital, and Department of Surgery, Faculty of Medicine, Laval University, Québec, QC, Canada G1S 4L8. />Berthod F
Moulin V
Pouliot R
Germain L
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Źródło:
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Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2004 Jun; Vol. 39 (Pt 3), pp. 263-75.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Jan. 2011- : Malden : Wiley-Blackwell
Original Publication: San Diego : Academic Press, [cl986]-
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MeSH Terms:
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Cell Culture Techniques*
Skin, Artificial*
Tissue Engineering/*methods
Animals ; Biocompatible Materials ; Collagen ; Gels ; Humans ; Models, Biological ; Neovascularization, Physiologic ; Skin/blood supply ; Skin/innervation ; Skin/ultrastructure ; Wound Healing
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Liczba referencji:
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126
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Substance Nomenclature:
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0 (Biocompatible Materials)
0 (Gels)
9007-34-5 (Collagen)
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Entry Date(s):
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Date Created: 20040525 Date Completed: 20041215 Latest Revision: 20070321
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Update Code:
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20240104
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DOI:
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10.1042/BA20030229
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PMID:
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15154837
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The field of skin tissue engineering is a paradigm for the various efforts towards the reconstruction of other tissues and organ substitutes. As skin replacement, this biotechnological approach has evolved from simple cultured autologous epidermal sheets to more complex bilayered cutaneous substitutes. The various types of such substitutes are herein presented with their intended use. However, two integrative characteristics are analysed more specifically because of their critical role: neovascularization and re-innervation. Furthermore, the in vitro use of these various skin substitutes has shed light on various physiological and pathological phenomena. Thus, not only the in vivo application of these skin substitutes as grafts, but also their in vitro value as skin models, are presented.