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Tytuł:
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Mixed chimerism of cardiomyocytes and vessels after allogeneic bone marrow and stem-cell transplantation in comparison with cardiac allografts.
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Autorzy:
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Thiele J; Institute of Pathology, University of Cologne, Joseph-Stelzmannstrasse 9, D-50924 Cologne, Germany. />Varus E
Wickenhauser C
Kvasnicka HM
Lorenzen J
Gramley F
Metz KA
Rivero F
Beelen DW
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Źródło:
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Transplantation [Transplantation] 2004 Jun 27; Vol. 77 (12), pp. 1902-5.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Williams & Wilkins.
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MeSH Terms:
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Stem Cell Transplantation*
Transplantation Chimera*
Bone Marrow Transplantation/*immunology
Coronary Vessels/*transplantation
Heart Transplantation/*immunology
Muscle Cells/*immunology
Myocardium/*immunology
Transplantation, Homologous/*immunology
Chromosomes, Human, X/genetics ; Chromosomes, Human, Y/genetics ; Coronary Vessels/immunology ; Female ; Humans ; Male
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Entry Date(s):
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Date Created: 20040630 Date Completed: 20040810 Latest Revision: 20190713
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Update Code:
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20240104
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DOI:
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10.1097/01.tp.0000127591.34203.8e
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PMID:
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15223912
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Controversy persists about mixed chimerism (mCh) occurring in the hearts of patients after orthotopic cardiac transplantation in comparison with allogeneic bone marrow (BM) and peripheral blood stem-cell (PBSC) transplants. Cadaver hearts were examined after sex-mismatched transplantation by immunophenotyping combined with dual color fluorescence in situ hybridization (X and Y chromosome-specific probes). A striking disparity in the extent of mCh depending on the different transplantation procedures was recognizable. After allografting with PBSCs, 1.7% chimeric cardiomyocytes were detectable contrasting 5.4% of donor cells after full BM transplantation. In cardiac transplants, host-type endothelial cells (16.2%) and myocytes (14.3%) of the vessel walls were more often encountered than after BM and PBSC allografting. A sprouting of vascular structures into the donor heart after orthotopic cardiac transplantation has to be assumed, as does a pivotal role of the mesenchymal stem cells of the BM in the development of mCh.