A facile synthetic method to prepare fluorescently labeled ROMP polymers.

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Tytuł:: A facile synthetic method to prepare fluorescently labeled ROMP polymers.
Autorzy:: Roberts KS; Department of Chemistry, State University of New York, Stony Brook, New York 11794-3400, USA.
Sampson NS
Źródło:: Organic letters [Org Lett] 2004 Sep 16; Vol. 6 (19), pp. 3253-5.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Język:: English
Imprint Name(s):: Original Publication: Washington, DC : American Chemical Society, c1999-
MeSH Terms:: Chemistry, Organic/*methods
Fluorescent Dyes/*chemical synthesis
Membrane Glycoproteins/*metabolism
Metalloendopeptidases/*chemical synthesis
Oligopeptides/*chemical synthesis
Polymers/*chemical synthesis
Receptors, Cell Surface/*metabolism
ADAM Proteins ; Animals ; Female ; Fertilins ; Male ; Membrane Glycoproteins/chemical synthesis ; Metalloendopeptidases/metabolism ; Mice ; Microscopy, Fluorescence ; Molecular Structure ; Oocytes/metabolism ; Spermatozoa/metabolism ; Stereoisomerism
Grant Information:: HD38519 United States HD NICHD NIH HHS
Substance Nomenclature:: 0 (Fluorescent Dyes)
0 (Membrane Glycoproteins)
0 (Oligopeptides)
0 (Polymers)
0 (Receptors, Cell Surface)
EC 3.4.24.- (ADAM Proteins)
EC 3.4.24.- (Fertilins)
EC 3.4.24.- (Metalloendopeptidases)
Entry Date(s):: Date Created: 20040910 Date Completed: 20050928 Latest Revision: 20161124
Update Code:: 20240104
DOI:: 10.1021/ol048935y
PMID:: 15355025
: Czasopismo naukowe

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[structure: see text] To probe the activities of sperm ADAM protein (fertilinbeta), we devised a general synthetic strategy to generate fluorescently labeled fertilinbeta oligopeptide polymers. Immunofluorescence studies with these polymers demonstrated that fertilinbeta polymers bind specifically to a protein receptor on the mouse egg plasma membrane.

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