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Tytuł pozycji:

Proposed function of the accumulation of plasma membrane-type Ca2+-ATPase mRNA in resting cysts of the ciliate Sterkiella histriomuscorum.

Tytuł:
Proposed function of the accumulation of plasma membrane-type Ca2+-ATPase mRNA in resting cysts of the ciliate Sterkiella histriomuscorum.
Autorzy:
Lescasse R; Laboratoire de Biologie Cellulaire 4, Université Paris-Sud, Orsay, France.
Grisvard J
Fryd G
Fleury-Aubusson A
Baroin-Tourancheau A
Źródło:
Eukaryotic cell [Eukaryot Cell] 2005 Jan; Vol. 4 (1), pp. 103-10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Washington, DC : American Society for Microbiology, c2002-
MeSH Terms:
Calcium-Transporting ATPases/*physiology
Cation Transport Proteins/*physiology
Oxytricha/*physiology
Animals ; Blotting, Northern ; Blotting, Southern ; Calcium/metabolism ; Calcium-Transporting ATPases/metabolism ; Cation Transport Proteins/metabolism ; Cell Membrane/metabolism ; Ciliophora/enzymology ; Cloning, Molecular ; DNA, Complementary/metabolism ; Gene Expression Profiling ; Mutation ; Oxytricha/enzymology ; Phylogeny ; Plasma Membrane Calcium-Transporting ATPases ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Temperature
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Substance Nomenclature:
0 (Cation Transport Proteins)
0 (DNA, Complementary)
0 (RNA, Messenger)
EC 3.6.3.8 (Plasma Membrane Calcium-Transporting ATPases)
EC 7.2.2.10 (Calcium-Transporting ATPases)
SY7Q814VUP (Calcium)
Entry Date(s):
Date Created: 20050112 Date Completed: 20050524 Latest Revision: 20191210
Update Code:
20240104
PubMed Central ID:
PMC544153
DOI:
10.1128/EC.4.1.103-110.2005
PMID:
15643066
Czasopismo naukowe
From an mRNA differential-display analysis of the encystment-excystment cycle of the ciliate Sterkiella histriomuscorum, we have isolated an expressed sequence tag encoding a plasma membrane-type Ca2+-ATPase (PMCA). PMCAs are located either in the plasma membranes or in the membranes of intracellular organelles, and their function is to pump calcium either out of the cell or into the intracellular calcium stores, respectively. The S. histriomuscorum macronuclear PMCA gene (ShPMCA) and its corresponding cDNA were cloned; it is the first member of the Ca2+-ATPase family identified in Sterkiella. The predicted protein of 1,065 amino acids exhibits 37% identity with PMCAs of diverse organisms. A phylogenetic analysis showed its relatedness to homologs of two alveolates: the ciliate Paramecium tetraurelia and the apicomplexan Toxoplasma gondii. Overexpression of the protein ShPMCA failed to rescue the wild-type phenotype of three Ca2+-ATPase-defective mutant strains of Saccharomyces cerevisiae; this failure contrasts with the reported ability of the PMCAs of parasites to complement defects in yeast. ShPMCA mRNA is markedly accumulated during encystment and in resting cysts, suggesting a function during excystment. To address the possibility of a signaling role for calcium at excystment, the capacity of calcium to induce excystment was examined.

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