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Tytuł:
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Primary lung adenocarcinoma with massive lymphocyte infiltration.
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Autorzy:
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Tsuta K; Pathology Division, National Cancer Center Research, Institute East and the Clinical Laboratory, National Cancer Center Hospital East, Chiba, Japan.
Ishii G
Kim E
Shiono S
Nishiwaki Y
Endoh Y
Kodama T
Nagai K
Nagai K
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Źródło:
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American journal of clinical pathology [Am J Clin Pathol] 2005 Apr; Vol. 123 (4), pp. 547-52.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2016- : Oxford : Oxford University Press
Original Publication: Philadelphia [etc.] Lippincott [etc.]
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MeSH Terms:
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Adenocarcinoma/*pathology
Lung Neoplasms/*pathology
Lymphocyte Subsets/*pathology
Lymphocytes, Tumor-Infiltrating/*pathology
Adenocarcinoma/classification ; Adenocarcinoma/immunology ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Lung Neoplasms/classification ; Lung Neoplasms/immunology ; Lymphatic Metastasis/pathology ; Lymphocyte Subsets/immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged
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Substance Nomenclature:
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0 (Biomarkers, Tumor)
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Entry Date(s):
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Date Created: 20050304 Date Completed: 20050512 Latest Revision: 20151119
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Update Code:
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20240104
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DOI:
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10.1309/APKQ-4Q9D-52GN-LR8W
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PMID:
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15743751
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We report 6 cases of adenocarcinoma with massive lymphocyte infiltration. This adenocarcinoma is found in 0.7% of surgically resected primary lung adenocarcinomas. The tumor was located in the peripheral portion in all cases. Lymph node metastasis was detected in 4 cases. The mean follow-up period was 49.8 months; all patients were alive without recurrence despite advanced pathologic stage. Histologically, the tumors revealed an acinar and glandular structure, and the cancer epithelium was destroyed by infiltrating lymphocytes. The lung parenchyma was destroyed by the severe inflammatory cell infiltration without dense fibrosis. Immunohistochemical staining revealed that most infiltrating lymphocytes were positive for CD3 or CD20. None of the tumors were positive for latent membrane protein-1, bcl-2, or Epstein-Barr virus-encoded small RNA-1. This type of adenocarcinoma occurs in old age, and good outcome and distinctive histologic features were observed. We refer to it as primary lung adenocarcinoma with massive lymphocyte infiltration.