Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons.

Szczegóły
Abstrakt

Tytuł:: Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons.
Autorzy:: Popov VI; Institute of Cell Biophysics, Academy of Sciences, Pushchino, Moscow Region, Russia.
Bocharova LS
Źródło:: Neuroscience [Neuroscience] 1992; Vol. 48 (1), pp. 53-62.
Typ publikacji:: Comparative Study; Journal Article
Język:: English
Imprint Name(s):: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
MeSH Terms:: Hibernation*
Hippocampus/*ultrastructure
Nerve Fibers/*ultrastructure
Neurons/*ultrastructure
Pyramidal Tracts/*ultrastructure
Sciuridae/*physiology
Synapses/*ultrastructure
Animals ; Arousal ; Endoplasmic Reticulum/ultrastructure ; Hippocampus/physiology ; Microscopy, Electron ; Microtubules/ultrastructure ; Nerve Fibers/physiology ; Neurons/physiology ; Pyramidal Tracts/physiology ; Synapses/physiology
Entry Date(s):: Date Created: 19920101 Date Completed: 19920612 Latest Revision: 20190712
Update Code:: 20240104
DOI:: 10.1016/0306-4522(92)90337-2
PMID:: 1584425
: Czasopismo naukowe

Mossy fibre synapses on the CA3 hippocampal neurons in the brain of ground squirrels repeatedly undergo a striking structural transformation during hibernation. In the middle of hibernation bout the giant complex mossy fibre synapses have a reduced number of dendritic spine infoldings that are smaller and have a decreased number of postsynaptic densities in comparison with mossy fibre synapses of active animals. Two hours after arousal all these parameters of mossy fibre synapses increase and significantly exceed their levels not only in torpid but in active euthermic animals between bouts of torpor. The longer postsynaptic densities and the greater proportion of perforated postsynaptic densities were found soon after arousal. These rapid, reversible and repeated changes indicate a cyclic process of partial denervation/reinnervation of hippocampal neurons by mossy fibres in the course of the innate, stereotyped behaviour.

Informacja