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Tytuł:
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The Drosophila lymph gland as a developmental model of hematopoiesis.
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Autorzy:
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Jung SH; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Evans CJ
Uemura C
Banerjee U
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Źródło:
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Development (Cambridge, England) [Development] 2005 Jun; Vol. 132 (11), pp. 2521-33. Date of Electronic Publication: 2005 Apr 27.
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Typ publikacji:
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Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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Język:
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English
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Imprint Name(s):
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Publication: Cambridge Eng : Company Of Biologists Limited
Original Publication: [Cambridge] : Company of Biologists, [c1987-
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MeSH Terms:
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Gene Expression Regulation, Developmental*
Models, Animal*
Drosophila/*embryology
Hematopoiesis, Extramedullary/*physiology
Hemocytes/*physiology
Lymphatic System/*embryology
Signal Transduction/*physiology
Animals ; Bromodeoxyuridine ; Gene Expression Profiling ; Immunohistochemistry ; Lymphatic System/anatomy & histology ; Lymphatic System/metabolism
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Grant Information:
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R01 HL67395 United States HL NHLBI NIH HHS; T32 HL69766 United States HL NHLBI NIH HHS
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Substance Nomenclature:
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G34N38R2N1 (Bromodeoxyuridine)
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Entry Date(s):
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Date Created: 20050429 Date Completed: 20050808 Latest Revision: 20131121
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Update Code:
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20240104
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DOI:
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10.1242/dev.01837
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PMID:
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15857916
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Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this systematic analysis of lymph gland structure and gene expression, we define the developmental steps in the maturation of blood cells (hemocytes) from their precursors. In particular, distinct zones of hemocyte maturation, signaling and proliferation in the lymph gland during hematopoietic progression are described. Different stages of hemocyte development have been classified according to marker expression and placed within developmental niches: a medullary zone for quiescent prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling center for specialized signaling hemocytes. This establishes a framework for the identification of Drosophila blood cells, at various stages of maturation, and provides a genetic basis for spatial and temporal events that govern hemocyte development. The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis.