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Tytuł pozycji:

Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.

Tytuł :
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Autorzy :
Terakawa M; Daiichi Suntory Biomedical Research Limited, 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8513, Japan.
Tomimori Y
Goto M
Hayashi Y
Oikawa S
Fukuda Y
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2005 Jul 15; Vol. 332 (4), pp. 969-75.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
MeSH Terms :
Eosinophils/*cytology
Eosinophils/*metabolism
Extracellular Signal-Regulated MAP Kinases/*metabolism
Mast Cells/*enzymology
Serine Endopeptidases/*chemistry
Animals ; Anthracenes/pharmacology ; Blotting, Western ; Butadienes/pharmacology ; Butyric Acid/chemistry ; Cell Line, Tumor ; Cell Movement ; Chemotaxis ; Chymases ; Enzyme Inhibitors/pharmacology ; Humans ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Mice, Inbred BALB C ; Mitogen-Activated Protein Kinase 3/metabolism ; Nitriles/pharmacology ; Pertussis Toxin/pharmacology ; Phosphorylation ; Pyridines/pharmacology ; Receptors, G-Protein-Coupled/metabolism ; Serine Endopeptidases/physiology ; Signal Transduction ; Time Factors ; p38 Mitogen-Activated Protein Kinases/metabolism
Substance Nomenclature :
0 (Anthracenes)
0 (Butadienes)
0 (Enzyme Inhibitors)
0 (Imidazoles)
0 (Nitriles)
0 (Pyridines)
0 (Receptors, G-Protein-Coupled)
0 (U 0126)
107-92-6 (Butyric Acid)
1TW30Y2766 (pyrazolanthrone)
EC 2.4.2.31 (Pertussis Toxin)
EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
EC 3.4.21.- (Serine Endopeptidases)
EC 3.4.21.39 (Chymases)
OU13V1EYWQ (SB 203580)
Entry Date(s) :
Date Created: 20050528 Date Completed: 20050804 Latest Revision: 20161124
Update Code :
20210210
DOI :
10.1016/j.bbrc.2005.04.172
PMID :
15919053
Czasopismo naukowe
Mast cell chymase is known to induce eosinophil migration in vivo and in vitro. In the present study, we investigated possible involvement of mitogen-activated protein (MAP) kinases; extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38, in the chymase-induced eosinophil migration. Human chymase induced a rapid phosphorylation of ERK1/2 and p38 in human eosinophilic leukemia EoL-1 cells, while no phosphorylation was detected in JNK. The chymase-induced phosphorylation of ERK and p38 was inhibited by pertussis toxin. Similar results were obtained in the experiments using mouse chymase and eosinophils. U0126 (the inhibitor for MAP/ERK kinase) suppressed chymase-induced migration of EoL-1 cells and mouse eosinophils. However, SB203580 (p38 inhibitor) and SP600125 (JNK inhibitor) showed little effect on the migration. It is suggested therefore that chymase activates ERK and p38 probably through G-protein-coupled receptor, and that ERK but not p38 cascade may have a crucial role in chymase-induced migration of eosinophils.

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