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Tytuł pozycji:

Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis.

Tytuł:
Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis.
Autorzy:
Liu X; Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Huddinge, Stockholm, Sweden.
Ciumas C
Huang YM
Steffensen KR
Lian H
Link H
Xiao BG
Źródło:
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2005 Aug; Vol. 11 (4), pp. 381-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2006- : London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
MeSH Terms:
Autoantigens/*pharmacology
Cytokines/*metabolism
Dendritic Cells/*immunology
Encephalomyelitis, Autoimmune, Experimental/*immunology
Growth Substances/*metabolism
Animals ; Cytokines/genetics ; DNA Primers ; Female ; Growth Substances/genetics ; Polymerase Chain Reaction ; Rats ; Rats, Inbred Lew
Substance Nomenclature:
0 (Autoantigens)
0 (Cytokines)
0 (DNA Primers)
0 (Growth Substances)
Entry Date(s):
Date Created: 20050727 Date Completed: 20050926 Latest Revision: 20170214
Update Code:
20240104
DOI:
10.1191/1352458505ms1180oa
PMID:
16042218
Czasopismo naukowe
Injection of myelin basic protein (MBP)-pulsed dendritic cells (DC) into healthy rats, as we reported before and observed in this study, did not induce clinical experimental allergic encephalomyelitis (EAE), but effectively protected the rats from subsequent EAE induction. The mechanisms by which MBP-pulsed DC mediate immune protection are not completely understood. In the present study, we mainly explored the dynamic change of cytokine and growth factor mRNA expression in spinal cords after subcutaneous injection of MBP-pulsed and unpulsed DC. The expression of interleukin (IL)-1, interferon-gamma and tumour necrosis factor-alpha as well as programmed death ligand (PDL)-1, PDL-2, signal transducer and activator of transcription (STAT)4, STAT6, matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinases (TIMP)-2 was increased on day 0 postimmunization (p.i.). The increase of IL-12 expression was observed on day 7 p.i., while the increase of IL-10 expression mainly occurred on day 14 p.i. Except downregulation of insulin-like growth factor-1, the expression of brain-derived neurotrophic factor, ciliary neurotrophic factor, fibroblast growth factor (FGF)-2 and platelet-derived growth factor (PDGF)-B/C as well as nerve growth factor receptor (NGF-R), FGF receptor, PDGF-R-alpha and beta was elevated on day 0 p.i., while the increase of TIMP and NGF was observed on days 0 and 7 p.i. There were no significant differences on MMP-2, spinal cord-derived growth factor and PDGF-A mRNA expression. In line with the suppression of EAE induced by MBP-pulsed DC, the dynamic change of cytokines and growth factors in spinal cords should constitute a beneficial microenvironment against EAE.

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