Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Sentinel lymph node radiolocalization in clinically negative neck oral cancer.

Tytuł :
Sentinel lymph node radiolocalization in clinically negative neck oral cancer.
Autorzy :
Terada A; Department of Head and Neck Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681 Japan.
Hasegawa Y
Goto M
Sato E
Hyodo I
Ogawa T
Nakashima T
Yatabe Y
Pokaż więcej
Źródło :
Head & neck [Head Neck] 2006 Feb; Vol. 28 (2), pp. 114-20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: New York, NY : John Wiley And Sons
Original Publication: New York, NY : J. Wiley, c1989-
MeSH Terms :
Radiopharmaceuticals*
Sentinel Lymph Node Biopsy*
Head and Neck Neoplasms/*diagnosis
Feasibility Studies ; Female ; Frozen Sections ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/pathology ; Humans ; Intraoperative Period ; Male ; Neoplasm Metastasis ; Technetium Tc 99m Sulfur Colloid ; Tomography, Emission-Computed, Single-Photon
Substance Nomenclature :
0 (Radiopharmaceuticals)
556Q0P6PB1 (Technetium Tc 99m Sulfur Colloid)
Entry Date(s) :
Date Created: 20050913 Date Completed: 20060907 Latest Revision: 20161124
Update Code :
20210623
DOI :
10.1002/hed.20305
PMID :
16155916
Czasopismo naukowe
Background: The sentinel node concept has become one of the most interesting topics in the treatment of head and neck cancer. The aim of this article is to report the results of our feasibility study and clinical application of sentinel lymph node (SLN) radiolocalization and biopsy in patients with clinically negative neck oral cancer.
Methods: Individuals with previously untreated N0 oral cancer participated in the study. The radioactive tracer used was 99m Tc phytate. Lymphoscintigrams were taken in the feasibility study, and fusion images of SPECT and CT were obtained in the clinical SLN biopsy (SLNB) group. In the feasibility study, metastases to SLNs and other nodes were analyzed in permanent specimens. In the clinical application group, we investigated the comparative effectiveness of multi-slice frozen section analysis and imprint cytology for the intraoperative diagnosis of SLNB.
Results: Fifteen individuals participated in the feasibility study. Six SLNs in five patients were cancer-positive, and two thirds of the SLNs were micrometastases. The SLN concept was established, and SLNs with the highest to the third highest radioactivity reflected the patients' neck status accurately. Twelve patients participated in the clinical application group of SLNB. Intraoperative diagnosis of the three hottest SLNs correctly predicted the neck status of 10 patients. Three patients underwent modified radical neck dissection on the basis of the intraoperative diagnosis of cancer metastasis to SLNs, whereas neck dissections were spared in patients with no evidence of such metastases. There were two false-negative cases. One involved a failure of the intraoperative diagnosis of SLNB, and the other had cancer-negative SLNs and cancer-positive non-SLNs. Considering intraoperative diagnosis, multi-slice frozen section analysis was found to be superior to imprint cytology in its sensitivity, specificity, and overall accuracy on a lymph node basis. No differences were found in any of these indices of intraoperative SLNB on a patient basis. The fusion images of SPECT and CT proved very useful during intraoperative SLNB.
Conclusions: The sentinel node concept was established in the head and neck region. Analyzing the three hottest SLNs suffices to predict a patient's neck status. Multi-slice frozen section analysis was shown to be superior to imprint cytology for detecting micrometastasis to SLN. Intraoperative SLNB based on fusion images of SPECT and CT proved to be an easy, accurate, and reliable method.
(Copyright 2005 Wiley Periodicals, Inc.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies