An unusual oxalylated tetramic acid from the New Zealand basidiomycete Chamonixia pachydermis.

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Abstrakt

Tytuł:: An unusual oxalylated tetramic acid from the New Zealand basidiomycete Chamonixia pachydermis.
Autorzy:: Lang G; Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Cole AL
Blunt JW
Munro MH
Źródło:: Journal of natural products [J Nat Prod] 2006 Jan; Vol. 69 (1), pp. 151-3.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Cincinnati, American Society of Pharmacognosy.
MeSH Terms:: Anti-Bacterial Agents/*chemistry
Bacillus subtilis/*drug effects
Basidiomycota/*chemistry
Pyrrolidinones/*chemistry
Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Molecular Structure ; New Zealand ; Nuclear Magnetic Resonance, Biomolecular ; Pyrrolidinones/isolation & purification ; Pyrrolidinones/pharmacology
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Pyrrolidinones)
0 (pachydermin)
503-83-3 (tetramic acid)
Entry Date(s):: Date Created: 20060131 Date Completed: 20060316 Latest Revision: 20061115
Update Code:: 20240104
DOI:: 10.1021/np050488n
PMID:: 16441090
: Czasopismo naukowe

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An unusual oxalylated tetramic acid, pachydermin (1), has been isolated from the New Zealand basidiomycete Chamonixiapachydermis. The full structure, which was not directly accessible by NMR methods, was deduced from that of a degradation product, 5-(3-chloro-4-hydroxybenzylidene)tetramic acid (2). The degradation product 2 exhibited mild antibacterial activity against Bacillus subtilis.

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