Four new isoflavonoids from the stem bark of Erythrina variegata.

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Tytuł:: Four new isoflavonoids from the stem bark of Erythrina variegata.
Autorzy:: Xiaoli L; Department of Natural Products Chemistry, Shenyang Pharmaceutical University, China.
Naili W
Sau WM
Chen AS
Xinsheng Y
Źródło:: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2006 Apr; Vol. 54 (4), pp. 570-3.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Tokyo, Pharmaceutical Society of Japan.
MeSH Terms:: Cell Proliferation/*drug effects
Erythrina/*chemistry
Isoflavones/*pharmacology
Plant Bark/*chemistry
Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Isoflavones/chemistry ; Isoflavones/isolation & purification ; Molecular Structure ; Osteosarcoma/pathology ; Plants, Medicinal ; Rats ; Tumor Cells, Cultured
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Antineoplastic Agents, Phytogenic)
0 (Isoflavones)
Entry Date(s):: Date Created: 20060406 Date Completed: 20060621 Latest Revision: 20190706
Update Code:: 20240104
DOI:: 10.1248/cpb.54.570
PMID:: 16595969
: Czasopismo naukowe

Bioassay-directed fractionation of the stem bark extract of Erythrina variegata L. has resulted in the isolation of three new isoflavones: 5,4'-dihydroxy-8-(3,3-dimethylallyl)-2''-methoxyisopropylfurano[4,5:6,7]isoflavone (1), 5,7,4'-trihydroxy-6-(3,3-dimethylallyloxiranylmethyl)isoflavone (2), 5,4'-dihydroxy-8-(3,3-dimethylallyl)-2''-hydroxymethyl-2''-methylpyrano[5,6:6,7]isoflavone (3) and a new isoflavanone, 5,4'-dihydroxy-2'-methoxy-8-(3,3-dimethylallyl)-2'',2''-dimethylpyrano[5,6:6,7]isoflavanone (4) together with seven known compounds, euchrenone b10 (5), isoerysenegalensein E (6), wighteone (7), laburnetin (8), lupiwighteone (9), erythrodiol (10), and oleanolic acid (11). The structures were determined on the basis of spectroscopic analyses and chemical evidence. The effect of these compounds on the proliferation of rat osteogenic sarcoma (UMR106) is also reported.

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