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Tytuł pozycji:

Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients.

Tytuł:
Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients.
Autorzy:
Soliman AS; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. />Bondy M
Webb CR
Schottenfeld D
Bonner J
El-Ghawalby N
Soultan A
Abdel-Wahab M
Fathy O
Ebidi G
Zhang Q
Greenson JK
Abbruzzese JL
Hamilton SR
Źródło:
International journal of cancer [Int J Cancer] 2006 Sep 15; Vol. 119 (6), pp. 1455-61.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 1995- : New York, NY : Wiley-Liss
Original Publication: 1966-1984 : Genève : International Union Against Cancer
MeSH Terms:
Adenocarcinoma/*genetics
Cell Cycle Proteins/*genetics
Genes, p53/*genetics
Genes, ras/*genetics
Mutation/*genetics
Nuclear Proteins/*genetics
Pancreatic Neoplasms/*genetics
Adenocarcinoma/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Case-Control Studies ; DNA, Neoplasm/analysis ; Egypt ; Exons/genetics ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/pathology ; Polymerase Chain Reaction ; United States
Grant Information:
5 P30 CA46592 United States CA NCI NIH HHS; CA K07 090241 United States CA NCI NIH HHS; R03 CA099513-01 United States CA NCI NIH HHS
Substance Nomenclature:
0 (Cell Cycle Proteins)
0 (DNA, Neoplasm)
0 (GADD45A protein, human)
0 (Nuclear Proteins)
Entry Date(s):
Date Created: 20060419 Date Completed: 20060912 Latest Revision: 20160303
Update Code:
20240104
DOI:
10.1002/ijc.21986
PMID:
16619252
Czasopismo naukowe
Variations in genetic mutations in pancreatic carcinoma between different populations have not been studied extensively, especially in developing countries where pancreatic cancer is rare. We studied the molecular pathology of 44 pancreatic carcinomas from patients residing in a heavily polluted region in the Nile River delta and compared the findings with tumors from 44 United States (US) patients. We evaluated K-ras mutations in codon 12, p53 mutations in exons 5-8, and Gadd45a mutations in exons 1 and 4. Overall, rates of K-ras, p53 and Gadd45 mutations were not statistically different in tumors of patients from Egypt and the US (67.4 vs. 63.4%; 27.3 vs. 36.4% and 9.1 vs. 4.5%, respectively). However, there were distinct differences in the specific types of K-ras and p53 mutations between the 2 groups. In K-ras, G --> T transversion mutation was more frequent in the tumors from Egypt than from the US (58.6 vs. 26.9%), whereas G --> C transversion was detected in 26.9% of US tumors but none from Egypt (p = 0.003). We also found a trend toward differences in the p53 exons in which mutations occurred, with higher frequency of exon 5 mutation and lower frequency of exon 6 mutation in Egyptian tumors. Logistic regression showed that K-ras G --> T transversion mutations and p53 exon 6 mutations were predicted by the country of residence of the patients. Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences.

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