Mitochondria in Parkinson disease: back in fashion with a little help from genetics.

Szczegóły
Abstrakt

Tytuł:: Mitochondria in Parkinson disease: back in fashion with a little help from genetics.
Autorzy:: Muqit MM; Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, England.
Gandhi S
Wood NW
Źródło:: Archives of neurology [Arch Neurol] 2006 May; Vol. 63 (5), pp. 649-54.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Chicago, American Medical Assn.
MeSH Terms:: Mitochondrial Diseases*/complications
Mitochondrial Diseases*/genetics
Mitochondrial Diseases*/pathology
Mitochondria/*pathology
Parkinson Disease/*pathology
Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Mitochondria/genetics ; Models, Biological ; Oncogene Proteins/genetics ; Parkinson Disease/etiology ; Parkinson Disease/genetics ; Protein Deglycase DJ-1 ; Protein Kinases/genetics
Substance Nomenclature:: 0 (Intracellular Signaling Peptides and Proteins)
0 (Oncogene Proteins)
EC 2.7.- (Protein Kinases)
EC 2.7.11.1 (PTEN-induced putative kinase)
EC 3.1.2.- (PARK7 protein, human)
EC 3.1.2.- (Protein Deglycase DJ-1)
Entry Date(s):: Date Created: 20060510 Date Completed: 20060628 Latest Revision: 20161128
Update Code:: 20240104
DOI:: 10.1001/archneur.63.5.649
PMID:: 16682534
: Czasopismo naukowe

Parkinson disease is a devastating neurodegenerative disorder with no known cure. Impairment in mitochondrial dysfunction is thought to play a major role in the pathogenesis. Recent genetic advances suggest that mitochondrial dysfunction may be the primary defect. Drugs that target the mitochondria may therefore represent the best hope for disease-modifying therapies in Parkinson disease.

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