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Tytuł pozycji:

Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils.

Tytuł :
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils.
Autorzy :
Terakawa M; Daiichi Asubio Pharma Co. Limited, Biomedical Research Laboratories, 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8513, Japan.
Tomimori Y
Goto M
Fukuda Y
Pokaż więcej
Źródło :
European journal of pharmacology [Eur J Pharmacol] 2006 May 24; Vol. 538 (1-3), pp. 175-81. Date of Electronic Publication: 2006 May 09.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
MeSH Terms :
Chemokines/*metabolism
Eosinophils/*drug effects
Neutrophils/*drug effects
Peritonitis/*pathology
Serine Endopeptidases/*pharmacology
Animals ; Butadienes/pharmacology ; Cell Line, Tumor ; Chemokine CXCL2 ; Chemokines/genetics ; Chymases ; Cytokines/genetics ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Eosinophils/metabolism ; Eosinophils/pathology ; Gene Expression/drug effects ; Humans ; Imidazoles/pharmacology ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Mice ; Mice, Inbred BALB C ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Neutrophils/metabolism ; Neutrophils/pathology ; Nitriles/pharmacology ; Peritonitis/genetics ; Peritonitis/metabolism ; Pertussis Toxin/pharmacology ; Pyridines/pharmacology ; Quinazolines/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Substance Nomenclature :
0 (Butadienes)
0 (Chemokine CXCL2)
0 (Chemokines)
0 (Cxcl2 protein, mouse)
0 (Cytokines)
0 (Enzyme Inhibitors)
0 (Imidazoles)
0 (Interleukin-8)
0 (Nitriles)
0 (Pyridines)
0 (Quinazolines)
0 (RNA, Messenger)
0 (SUN-C 8257)
0 (U 0126)
EC 2.4.2.31 (Pertussis Toxin)
EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
EC 3.4.21.- (Serine Endopeptidases)
EC 3.4.21.39 (Chymases)
OU13V1EYWQ (SB 203580)
Entry Date(s) :
Date Created: 20060513 Date Completed: 20060816 Latest Revision: 20161128
Update Code :
20210210
DOI :
10.1016/j.ejphar.2006.03.053
PMID :
16690053
Czasopismo naukowe
Human chymase induced release of interleukin-8 (IL-8) in human EoL-1 cells that had been differentiated into eosinophil-like cells with butyric acid. The chymase-induced IL-8 production was specific in that other cytokines/chemokines examined were not induced. Human chymase also increased mRNA for IL-8 in the differentiated EoL-1 cells, showing involvement of mRNA synthesis. The chymase-induced IL-8 release was inhibited by pertussis toxin as well as U0126 (an inhibitor for extracellular signal-regulated kinase pathway) and SB203580 (p38 inhibitor), suggesting that the chymase-induced IL-8 production is mediated by G protein-coupled receptor and mitogen-activated protein kinases. Mouse mast cell protease-4 (mMCP-4), a mouse chymase, induced macrophage-inflammatory protein-2 (MIP-2), a mouse homologue for IL-8, in mouse eosinophils in vitro. Intradermal injection of mMCP-4 not only induced skin edema but increased MIP-2 content and neutrophil number at the injection site. Taken together, our findings demonstrate that mast cell chymase may contribute to the interaction between eosinophils and neutrophils by inducing IL-8/MIP-2 in eosinophils at allergic inflamed sites.

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