Synthesis and biological activity of amide derivatives of nimbolide.

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Tytuł:: Synthesis and biological activity of amide derivatives of nimbolide.
Autorzy:: Sastry BS; Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad.
Suresh Babu K
Hari Babu T
Chandrasekhar S
Srinivas PV
Saxena AK
Madhusudana Rao J
Źródło:: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Aug 15; Vol. 16 (16), pp. 4391-4. Date of Electronic Publication: 2006 Jun 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, c1991-
MeSH Terms:: Amides/*chemistry
Antineoplastic Agents/*pharmacology
Limonins/*chemistry
Azadirachta/metabolism ; Cell Line, Tumor ; Chemistry, Pharmaceutical/methods ; Drug Design ; Humans ; Inhibitory Concentration 50 ; Models, Chemical ; Plant Extracts/metabolism ; Plant Leaves ; Plants, Medicinal/metabolism
Substance Nomenclature:: 0 (Amides)
0 (Antineoplastic Agents)
0 (Limonins)
0 (Plant Extracts)
25990-37-8 (nimbolide)
Entry Date(s):: Date Created: 20060624 Date Completed: 20061006 Latest Revision: 20061115
Update Code:: 20240104
DOI:: 10.1016/j.bmcl.2006.05.105
PMID:: 16793266
: Czasopismo naukowe

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Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.

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