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Tytuł pozycji:

Antagonistic actions of halothane and sevoflurane on spontaneous Ca2+ release in rat ventricular myocytes.

Tytuł :
Antagonistic actions of halothane and sevoflurane on spontaneous Ca2+ release in rat ventricular myocytes.
Autorzy :
Graham MD; Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, UK.
Hopkins PM
Harrison SM
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Źródło :
Anesthesiology [Anesthesiology] 2006 Jul; Vol. 105 (1), pp. 58-64.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: Philadelphia Pa : Lippincott Williams & Wilkins
Original Publication: Philadelphia : American Society of Anesthesiologists
MeSH Terms :
Calcium/*antagonists & inhibitors
Halothane/*pharmacology
Methyl Ethers/*pharmacology
Myocytes, Cardiac/*drug effects
Myocytes, Cardiac/*metabolism
Animals ; Calcium/metabolism ; Heart Ventricles/drug effects ; Heart Ventricles/metabolism ; In Vitro Techniques ; Rats ; Sevoflurane
Substance Nomenclature :
0 (Methyl Ethers)
38LVP0K73A (Sevoflurane)
SY7Q814VUP (Calcium)
UQT9G45D1P (Halothane)
Entry Date(s) :
Date Created: 20060701 Date Completed: 20060811 Latest Revision: 20190628
Update Code :
20210623
DOI :
10.1097/00000542-200607000-00013
PMID :
16809995
Czasopismo naukowe
Background: Halothane has been reported to sensitize Ca(2+) release from the sarcoplasmic reticulum (SR), which is thought to contribute to its initial positive inotropic effect. However, little is known about whether isoflurane or sevoflurane affect the SR Ca(2+) release process, which may contribute to the inotropic profile of these anesthetics.
Methods: Mild Ca(2+) overload was induced in isolated rat ventricular myocytes by increase of extracellular Ca(2+) to 2 mM. The resultant Ca(2+) transients due to spontaneous Ca(2+) release from the SR were detected optically (fura-2). Cells were exposed to 0.6 mM anesthetic for a period of 4 min, and the frequency and amplitude of spontaneous Ca(2+) transients were measured.
Results: Halothane caused a temporary threefold increase in frequency and decreased the amplitude (to 54% of control) of spontaneous Ca(2+) transients. Removal of halothane inhibited spontaneous Ca release before it returned to control. In contrast, sevoflurane initially inhibited frequency of Ca(2+) release (to 10% of control), whereas its removal induced a burst of spontaneous Ca(2+) release. Isoflurane had no significant effect on either frequency or amplitude of spontaneous Ca(2+) release on application or removal. Sevoflurane was able to ameliorate the effects of halothane on the frequency and amplitude of spontaneous Ca(2+) release both on application and wash-off.
Conclusions: Application of halothane and removal of sevoflurane sensitize the SR Ca(2+) release process (and vice versa on removal). Sevoflurane reversed the effects of halothane, suggesting they may act at the same subcellular target on the SR.

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