Inflammation and extracellular volume expansion are related to sodium and water removal in patients on peritoneal dialysis.

Tytuł:: Inflammation and extracellular volume expansion are related to sodium and water removal in patients on peritoneal dialysis.
Autorzy:: Avila-Díaz M; Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México. />Ventura MD
Valle D
Vicenté-Martínez M
García-González Z
Cisneros A
Furlong MD
Gómez AM
Prado-Uribe MD
Amato D
Paniagua R
Źródło:: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis [Perit Dial Int] 2006 Sep-Oct; Vol. 26 (5), pp. 574-80.
Typ publikacji:: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2020- : [Thousand Oaks, CA] : SAGE Publications
Original Publication: New York : Pergamon Press, c1988-
MeSH Terms:: Extracellular Fluid/*metabolism
Inflammation/*etiology
Kidney Failure, Chronic/*therapy
Peritoneal Dialysis/*adverse effects
Sodium/*metabolism
Adult ; C-Reactive Protein/metabolism ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Inflammation/metabolism ; Kidney Failure, Chronic/metabolism ; Male ; Middle Aged ; Peritoneal Dialysis/mortality ; Prospective Studies ; Risk Factors
Substance Nomenclature:: 9007-41-4 (C-Reactive Protein)
9NEZ333N27 (Sodium)
Entry Date(s):: Date Created: 20060916 Date Completed: 20061219 Latest Revision: 20220316
Update Code:: 20240104
PMID:: 16973513
: Czasopismo naukowe

Background: Inflammation is an important risk for mortality in dialysis patients. Extracellular fluid volume (ECFv) expansion, a condition commonly seen in peritoneal dialysis (PD) patients, may be associated with inflammation. However, published support for this relationship is scarce.
Objectives: To quantify the proportion of patients on PD with inflammation and to analyze the role of ECFv expansion and the factors related to these conditions.
Design: A prospective, multicenter cross-sectional study in six hospitals with a PD program.
Patients and Methods: Adult patients on PD were studied. Clinical data, body composition, and sodium and fluid intake were recorded. Biochemical analysis, C-reactive protein (CRP), and peritoneal and urinary fluid and sodium removal were also measured.
Results: CRP values positive (>or=3.0 mg/L) for inflammation were found in 147 (80.3%) and negative in 36 patients. Patients with positive CRP had higher ECFv/total body water (TBW) ratio (women 47.69 +/- 0.69 vs 47.36 +/- 0.65, men 43.15 +/- 1.14 vs 42.84 +/- 0.65; p < 0.05), higher serum glucose (125.09 +/- 81.90 vs 103.28 +/- 43.30 mg/dL, p < 0.03), and lower serum albumin (2.86 +/- 0.54 vs 3.17 +/- 0.38 g/dL, p < 0.001) levels. They also had lower ultrafiltration (1003 +/- 645 vs 1323 +/- 413 mL/day, p < 0.005) and total fluid removal (1260 +/- 648 vs 1648 +/- 496 mL/day, p < 0.001), and less peritoneal (15.59 +/- 162.14 vs 78.11 +/- 110.70 mEq/day, p < 0.01) and total sodium removal (42.06 +/- 142.49 vs 118.60 +/- 69.73 mEq/day, p < 0.001). In the multivariate analysis, only ECFv/TBW was significantly (p < 0.04) and independently associated with inflammation. ECFv/TBW was correlated with fluid removal (r = 0.16, p < 0.03) and renal sodium removal (r = 0.2, p < 0.01).
Conclusion: The data suggest that ECFv expansion may have a significant role as an inflammatory stimulus. The results disclose a relationship between the two variables, ECFv expansion and inflammation, identified as independent risk factors for mortality in PD patients.

Comment in: Perit Dial Int. 2006 Sep-Oct;26(5):566-70. (PMID: 16973511)

Informacja