Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire.

Szczegóły
Abstrakt

Tytuł:: Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire.
Autorzy:: Epstein JB; Department of Oral Medicine and Diagnostic Sciences, College of Dentistry and Chicago Cancer Center, University of Illinois, Chicago, Illinois 60612, USA. />Beaumont JL
Gwede CK
Murphy B
Garden AS
Meredith R
Le QT
Brizel D
Isitt J
Cella D
Źródło:: Cancer [Cancer] 2007 May 01; Vol. 109 (9), pp. 1914-22.
Typ publikacji:: Journal Article; Multicenter Study; Validation Study
Język:: English
Imprint Name(s):: Publication: <2005- >: Hoboken, NJ : Wiley
Original Publication: New York [etc.] Published for the American Cancer Society by J. Wiley [etc.]
MeSH Terms:: Surveys and Questionnaires*
Head and Neck Neoplasms/*radiotherapy
Stomatitis/*psychology
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/adverse effects ; Combined Modality Therapy ; Evaluation Studies as Topic ; Female ; Head and Neck Neoplasms/drug therapy ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Radiotherapy/adverse effects ; Reproducibility of Results ; Stomatitis/etiology
Substance Nomenclature:: 0 (Antineoplastic Agents)
Entry Date(s):: Date Created: 20070323 Date Completed: 20070626 Latest Revision: 20220316
Update Code:: 20240104
DOI:: 10.1002/cncr.22620
PMID:: 17377917
: Czasopismo naukowe

Full Text Finder

Background: Quality-of-life instruments that measure specific functional consequences of mucositis are needed to assess the efficacy of therapeutic interventions targeted against mucositis and to guide patient care. The authors undertook a prospective, multicenter, observational study to assess the validity, reliability, and feasibility of a new instrument, the Oral Mucositis Weekly Questionnaire-Head and Neck Cancer (OMWQ-HN). The OMWQ-HN is a patient-reported outcome questionnaire that measures the symptoms of mucositis, including mouth and throat soreness (MTS), and their impact on patient well-being and function.
Methods: The OMWQ-HN, along with the Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN), was administered 5 times over an approximately 6-week period to patients with head and neck cancer (HNC) who were receiving radiation therapy with or without chemotherapy. Information on supportive care measures also was collected.
Results: Seventy-five patients were enrolled and completed 93% of scheduled assessments (100% at baseline). The OMWQ-HN demonstrated good test-retest reliability (correlation coefficient, 0.80-0.89). Cross-sectional analyses to assess validity showed that OMWQ-HN scores were different across levels of pain, with those in the worst pain category reporting the highest OMWQ-HN scores. Strong correlations were observed between OMWQ-HN and FACT-HN. Patients experienced increases in MTS, which corresponded with a steady decline in function. MTS scores were highest in the patients who were taking opioid analgesics, suggesting that mucositis pain continued despite standard pain therapy.
Conclusions: The current results indicated that the OMWQ-HN is a valid, reliable, and feasible instrument for assessing the impact of mucositis on patients who are receiving radiation therapy with or without chemotherapy for HNC.
(Copyright (c) 2007 American Cancer Society)

Informacja