-
Tytuł:
-
In vivo confocal microscopy of subepithelial infiltrates in human corneal transplant rejection.
-
Autorzy:
-
Niederer RL; Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Sherwin T
McGhee CN
-
Źródło:
-
Cornea [Cornea] 2007 May; Vol. 26 (4), pp. 501-4.
-
Typ publikacji:
-
Case Reports; Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, N.Y. : Masson Pub. USA, c1982-
-
MeSH Terms:
-
Keratoplasty, Penetrating*
Dendritic Cells/*pathology
Epithelium, Corneal/*pathology
Graft Rejection/*diagnosis
Langerhans Cells/*pathology
Microscopy, Confocal/*methods
Female ; Humans ; Male ; Middle Aged ; Transplantation, Homologous
-
Entry Date(s):
-
Date Created: 20070426 Date Completed: 20070604 Latest Revision: 20220330
-
Update Code:
-
20240104
-
DOI:
-
10.1097/ICO.0b013e3180318107
-
PMID:
-
17457206
-
Purpose: Corneal allograft rejection is the leading cause of penetrating keratoplasty failure in the first year after surgery. We report 2 cases of subepithelial infiltrates in corneal transplant rejection imaged by in vivo confocal microscopy.
Methods: Case report and review of relevant literature.
Results: Two subjects with subepithelial infiltrates in previously clear penetrating corneal transplants were assessed. In vivo confocal microscopy revealed focal accumulations of hyperreflective dendritic-like particles, postulated to represent Langerhans cells, at the level of the basal epithelium and Bowman membrane. Altered keratocytes with visible cytoplasmic processes were observed posterior to these foci.
Conclusions: To our knowledge, these are the first reported cases of in vivo confocal microscopy appearance of corneal allograft rejection in humans. In vivo confocal microscopy may provide a valuable clinical tool to aid in the diagnosis of early corneal transplant rejection and in the differential diagnosis of other inflammatory conditions of the cornea.
