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Tytuł:
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In vivo confocal microscopy of subepithelial infiltrates in human corneal transplant rejection.
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Autorzy:
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Niederer RL; Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Sherwin T
McGhee CN
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Źródło:
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Cornea [Cornea] 2007 May; Vol. 26 (4), pp. 501-4.
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Typ publikacji:
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Case Reports; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, N.Y. : Masson Pub. USA, c1982-
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MeSH Terms:
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Keratoplasty, Penetrating*
Dendritic Cells/*pathology
Epithelium, Corneal/*pathology
Graft Rejection/*diagnosis
Langerhans Cells/*pathology
Microscopy, Confocal/*methods
Female ; Humans ; Male ; Middle Aged ; Transplantation, Homologous
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Entry Date(s):
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Date Created: 20070426 Date Completed: 20070604 Latest Revision: 20220330
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Update Code:
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20240104
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DOI:
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10.1097/ICO.0b013e3180318107
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PMID:
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17457206
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Purpose: Corneal allograft rejection is the leading cause of penetrating keratoplasty failure in the first year after surgery. We report 2 cases of subepithelial infiltrates in corneal transplant rejection imaged by in vivo confocal microscopy.
Methods: Case report and review of relevant literature.
Results: Two subjects with subepithelial infiltrates in previously clear penetrating corneal transplants were assessed. In vivo confocal microscopy revealed focal accumulations of hyperreflective dendritic-like particles, postulated to represent Langerhans cells, at the level of the basal epithelium and Bowman membrane. Altered keratocytes with visible cytoplasmic processes were observed posterior to these foci.
Conclusions: To our knowledge, these are the first reported cases of in vivo confocal microscopy appearance of corneal allograft rejection in humans. In vivo confocal microscopy may provide a valuable clinical tool to aid in the diagnosis of early corneal transplant rejection and in the differential diagnosis of other inflammatory conditions of the cornea.