Clinical heterogeneity in autoimmune acute liver failure.

Szczegóły
Abstrakt

Tytuł:: Clinical heterogeneity in autoimmune acute liver failure.
Autorzy:: Chavez-Tapia NC; Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga #5. Col. Seccion XVI. Del. Tlalpan. CP 14000, Distrito Federal, Mexico. />Martinez-Salgado J
Granados J
Uribe M
Tellez-Avila FI
Źródło:: World journal of gastroenterology [World J Gastroenterol] 2007 Mar 28; Vol. 13 (12), pp. 1824-7.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998-
MeSH Terms:: Hepatitis, Autoimmune/*complications
Liver Failure, Acute/*diagnosis
Liver Failure, Acute/*immunology
Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Cohort Studies ; Female ; Hepatitis, Autoimmune/drug therapy ; Humans ; Liver Failure, Acute/mortality ; Liver Transplantation ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Survival Rate ; Treatment Outcome
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Substance Nomenclature:: 0 (Adrenal Cortex Hormones)
Entry Date(s):: Date Created: 20070501 Date Completed: 20070816 Latest Revision: 20240321
Update Code:: 20240321
PubMed Central ID:: PMC4149960
DOI:: 10.3748/wjg.v13.i12.1824
PMID:: 17465474
: Czasopismo naukowe

Aim: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation.
Methods: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed.
Results: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids.
Conclusion: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids.

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