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Title of the item:

The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural.

Title :
The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural.
Authors :
Matzi V; Department of Surgery, Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria.
Lindenmann J
Muench A
Greilberger J
Juan H
Wintersteiger R
Maier A
Smolle-Juettner FM
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Source :
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery [Eur J Cardiothorac Surg] 2007 Nov; Vol. 32 (5), pp. 776-82. Date of Electronic Publication: 2007 Sep 04.
Publication Type :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Language :
English
Imprint Name(s) :
Publication: 2012-: Oxford, England : Oxford University Press
Original Publication: [Berlin] : Springer International ; [Secaucus, NJ, USA : Springer-Verlag New York Inc., distributor, c1987-
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*surgery
Furaldehyde/*analogs & derivatives
Ketoglutaric Acids/*administration & dosage
Lung Neoplasms/*surgery
Micronutrients/*administration & dosage
Pulmonary Surgical Procedures/*methods
Administration, Oral ; Aged ; Female ; Furaldehyde/administration & dosage ; Humans ; Male ; Middle Aged ; Preoperative Care ; Prospective Studies ; Regression Analysis
Substance Nomenclature :
0 (Ketoglutaric Acids)
0 (Micronutrients)
70ETD81LF0 (5-hydroxymethylfurfural)
DJ1HGI319P (Furaldehyde)
Entry Date(s) :
Date Created: 20070905 Date Completed: 20080228 Latest Revision: 20181201
Update Code :
20210623
DOI :
10.1016/j.ejcts.2007.07.016
PMID :
17768058
Academic Journal
Objective: Preoperative micronutrient supplementation in fast-track surgery programs have shown to reduce complications, shorten recovery, and thereby lower costs. In a prospective randomized study, the metabolic effects of a combination of alpha-ketoglutaric acid (alpha-KG) and 5-hydroxymethylfurfural (5-HMF) were evaluated concerning their impact on improvement of exercise capacity and reduction of oxidative stress in lung surgery.
Methods: Thirty-two consecutive patients admitted for lung resection due to NSCLC were randomized to the study protocol. All patients received preoperative nutritional guidelines according to general recommendations. In 16 (study group), a supplementation of 7.2g alpha-KG and 720 mg 5-HMF/day (SANOPAL) was administered from days 1 to 10. Spiroergometric evaluation was carried out at baseline and day 10 after micronutrient supplementation. Blood samples for the determination of oxidative stress, i.e. carbonyl proteins (CPs) and isoprostanes (IPs) were taken on at baseline, in the operating room just before resection treatment, and 25 min after single lung ventilation (SLV).
Results: Spiroergometric re-evaluation showed a significant increase of VO2max (p=0.0108) and Watt's (p=0.011) in favor of the study group. Determination of oxidative stress showed a significant reduction of CPs before (p=0.048) and after SLV (p=0.0001) for the study group compared to the control group. The same is true for IPs before (p=0.003) and after SLV (p=0.02). Hospitalization and intensive care unit (ICU) of the study group showed a significant reduction compared to the control group (p=0.03 and p=0.02, respectively).
Conclusions: Simple oral supplementation using a combination of alpha-KG and 5-HMF of preoperative micronutrition may therefore be one further step in a multimodality approach of fast-track surgery programs also in lung surgery.

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