Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Reversible reduction in dendritic spines in CA1 of rat and ground squirrel subjected to hypothermia-normothermia in vivo: A three-dimensional electron microscope study.

Tytuł :
Reversible reduction in dendritic spines in CA1 of rat and ground squirrel subjected to hypothermia-normothermia in vivo: A three-dimensional electron microscope study.
Autorzy :
Popov VI; The Open University, Department of Biological Sciences, Faculty of Sciences, Walton Hall, Milton Keynes MK7 6AA, UK.
Medvedev NI
Patrushev IV
Ignat'ev DA
Morenkov ED
Stewart MG
Pokaż więcej
Źródło :
Neuroscience [Neuroscience] 2007 Nov 09; Vol. 149 (3), pp. 549-60. Date of Electronic Publication: 2007 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
MeSH Terms :
Dendritic Spines/*pathology
Dendritic Spines/*ultrastructure
Hippocampus/*pathology
Hippocampus/*ultrastructure
Hypothermia/*pathology
Sciuridae/*physiology
Animals ; Arousal/physiology ; Astrocytes/pathology ; Astrocytes/ultrastructure ; Axons/pathology ; Axons/ultrastructure ; Cell Count ; Female ; Hibernation/physiology ; Image Processing, Computer-Assisted ; Male ; Microscopy, Electron ; Nerve Net/pathology ; Nerve Net/ultrastructure ; Presynaptic Terminals/pathology ; Presynaptic Terminals/ultrastructure ; Rats ; Rats, Wistar ; Synapses/pathology ; Synapses/ultrastructure
Entry Date(s) :
Date Created: 20071009 Date Completed: 20080116 Latest Revision: 20080609
Update Code :
20210210
DOI :
10.1016/j.neuroscience.2007.07.059
PMID :
17919827
Czasopismo naukowe
A study was made at electron microscope level of changes in the three-dimensional (3-D) morphology of dendritic spines and postsynaptic densities (PSDs) in CA1 of the hippocampus in ground squirrels, taken either at low temperature during hibernation (brain temperature 2-4 degrees C), or after warming and recovery to the normothermic state (34 degrees C). In addition, the morphology of PSDs and spines was measured in a non-hibernating mammal, rat, subjected to cooling at 2 degrees C at which time core rectal temperature was 15 degrees C, and then after warming to normothermic conditions. Significant differences were found in the proportion of thin and stubby spines, and shaft synapses in CA1 for rats and ground squirrels for normothermia compared with cooling or hibernation. Hypothermia induced a decrease in the proportion of thin spines, and an increase in stubby and shaft spines, but no change in the proportion of mushroom spines. The changes in redistribution of these three categories of spines in ground squirrel are more prominent than in rat. There were no significant differences in synapse density determined for ground squirrels or rats at normal compared with low temperature. Measurement of spine and PSD volume (for mushroom and thin spines) also showed no significant differences between the two functional states in either rats or ground squirrels, nor were there any differences in distances between neighboring synapses. Spinules on dendritic shafts were notable qualitatively during hibernation, but absent in normothermia. These data show that hypothermia results in morphological changes which are essentially similar in both a hibernating and a non-hibernating animal.
Erratum in: Neuroscience. 2008 Apr 9;152(4):1145.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies