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Title of the item:

Both senescence and apoptosis induced by deprivation of growth factors were inhibited by a novel butyrolactone derivative through depressing integrin beta4 in vascular endothelial cells.

Title :
Both senescence and apoptosis induced by deprivation of growth factors were inhibited by a novel butyrolactone derivative through depressing integrin beta4 in vascular endothelial cells.
Authors :
Wang W; Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, PR China.
Liu X
Zhang Y
Zhao J
Zhao B
Zhang S
Miao J
Show more
Source :
Endothelium : journal of endothelial cell research [Endothelium] 2007 Nov-Dec; Vol. 14 (6), pp. 325-32.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
Language :
English
Imprint Name(s) :
Publication: May/June 2006-Sept./Dec. 20 : London : Informa Healthcare
Original Publication: Yverdon, Switzerland : New York, N.Y. : Harwood Academic Publishers, c1993-
MeSH Terms :
Apoptosis*
Cellular Senescence*
Endothelial Cells/*cytology
Endothelial Cells/*drug effects
Furans/*pharmacology
Integrin beta4/*metabolism
Intercellular Signaling Peptides and Proteins/*deficiency
Cells, Cultured ; DNA Fragmentation/drug effects ; Endothelial Cells/enzymology ; Enzyme Activation/drug effects ; Fibroblast Growth Factor 2/deficiency ; Humans ; Serum ; beta-Galactosidase/metabolism
Substance Nomenclature :
0 (Furans)
0 (Integrin beta4)
0 (Intercellular Signaling Peptides and Proteins)
103107-01-3 (Fibroblast Growth Factor 2)
EC 3.2.1.23 (beta-Galactosidase)
Entry Date(s) :
Date Created: 20071218 Date Completed: 20080215 Latest Revision: 20171116
Update Code :
20210623
DOI :
10.1080/10623320701746206
PMID :
18080869
Academic Journal
Both senescence and apoptosis of vascular endothelial cells (VECs) are involved in the development of cardiovascular diseases, including atherosclerosis. To understand the association between senescence and apoptosis in vascular endothelial cells, the authors first explored whether senescence and apoptosis took place at the same time in human umbilical vein endothelial cells (HUVECs) deprived of the growth factors. Integrin beta4 is a key factor in HUVEC apoptosis, to know whether this integrin is implicated in VEC senescence, the authors checked the changes of integrin beta4 level during HUVEC aging. Then the authors investigated the effects of 3BDO (3-benzyl-5-((2-nitrophenoxy)methyl)-dihydrofuran-2(3H)-one) on the senescence induced by deprivation of serum and fibroblast growth factor (FGF)-2. The results showed that deprivation of growth factors not only induced apoptosis, but also triggered senescence in HUVECs. The authors found that the level of integrin beta 4 was increased markedly during HUVEC senescence. 3BDO (20 to 60 microg/mL) could inhibit both senescence and apoptosis and depress integrin beta 4 level. The data suggested that integrin beta4 might be a pivotal factor in the relationship between senescence and apoptosis.

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