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Tytuł pozycji:

Relative influences of adjunctive topiramate and adjunctive lamotrigine on scanning and the effective field of view.

Tytuł :
Relative influences of adjunctive topiramate and adjunctive lamotrigine on scanning and the effective field of view.
Autorzy :
Mills KC; Profile Associates, Chapel Hill, NC, United States. />Drazkowski JF
Hammer AE
Caldwell PT
Kustra RP
Blum DE
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Źródło :
Epilepsy research [Epilepsy Res] 2008 Feb; Vol. 78 (2-3), pp. 140-6. Date of Electronic Publication: 2007 Dec 21.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Amsterdam : Elsevier Science Publishers, c1987-
MeSH Terms :
Anticonvulsants/*adverse effects
Epilepsy/*complications
Fructose/*analogs & derivatives
Triazines/*adverse effects
Vision Disorders/*chemically induced
Visual Fields/*drug effects
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticonvulsants/therapeutic use ; Cognition/drug effects ; Data Interpretation, Statistical ; Double-Blind Method ; Drug Therapy, Combination ; Epilepsy/drug therapy ; Female ; Fructose/adverse effects ; Fructose/therapeutic use ; Humans ; Lamotrigine ; Male ; Middle Aged ; Neuropsychological Tests ; Seizures/drug therapy ; Seizures/epidemiology ; Topiramate ; Triazines/therapeutic use ; Vision Disorders/psychology ; Visual Perception/drug effects
Substance Nomenclature :
0 (Anticonvulsants)
0 (Triazines)
0H73WJJ391 (Topiramate)
30237-26-4 (Fructose)
U3H27498KS (Lamotrigine)
Entry Date(s) :
Date Created: 20071225 Date Completed: 20080423 Latest Revision: 20181201
Update Code :
20210209
DOI :
10.1016/j.eplepsyres.2007.10.013
PMID :
18155445
Czasopismo naukowe
A subsample of 67 adult patients with partial seizures participating in a randomized, double-blind study comparing the cognitive effects of adjunctive lamotrigine (LTG) and adjunctive topiramate (TPM) was administered Performance On-Line (POL) in addition to a battery of neuropsychological tests at baseline, week 8 and week 16 of treatment. The POL is a self-administered computer task that measures scanning, divided-attention, and the effective field of view. Although the POL does not measure driving performance, POL scores are correlated with driving performance. The results show that adjunctive TPM, but not adjunctive LTG, negatively impacted cognition. Both simple target identification and divided-attention performance on POL were compromised in the TPM group but not in the LTG group. The relative POL impairment associated with chronic TPM treatment was similar to that observed with the acute effects of alcohol with a breath level of .045% or a low dose of alprazolam (0.5mg). Thus, driving-related visual and cognitive skills were compromised by adjunctive TPM treatment. Therapeutic doses of adjunctive TPM pose a potential risk of impaired scanning and divided-attention skills.
Erratum in: Epilepsy Res. 2009 Sep;86(1):99.

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