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Tytuł pozycji:

Systemic venous thrombosis after recombinant factor VIIa in the control of bleeding after cardiac surgery.

Tytuł:
Systemic venous thrombosis after recombinant factor VIIa in the control of bleeding after cardiac surgery.
Autorzy:
Mahmoud A; Leeds General Infirmary, Leeds LS1 3EX, United Kingdom.
Al-Ruzzeh S
McKeague H
Cross M
Źródło:
Texas Heart Institute journal [Tex Heart Inst J] 2007; Vol. 34 (4), pp. 485-8.
Typ publikacji:
Case Reports; Journal Article
Język:
English
Imprint Name(s):
Original Publication: Houston, TX : published in the Cardiovascular Surgical Research Laboratories, Texas Heart Institute, c1982-
MeSH Terms:
Jugular Veins*
Subclavian Vein*
Coronary Artery Bypass/*methods
Factor VIIa/*adverse effects
Postoperative Hemorrhage/*drug therapy
Venous Thrombosis/*chemically induced
Aged ; Factor VIIa/therapeutic use ; Fatal Outcome ; Female ; Humans ; Recombinant Proteins/adverse effects ; Recombinant Proteins/therapeutic use ; Venous Thrombosis/diagnosis
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Contributed Indexing:
Keywords: Blood coagulation/drug effects; blood loss, surgical/prevention & control; cardiopulmonary bypass; factor VIIa/adverse effects/therapeutic use; hemostatics/adverse effects; postoperative hemorrhage/drug therapy; recombinant proteins/therapeutic use; treatment failure; treatment outcome; venous thrombosis/etiology
Substance Nomenclature:
0 (Recombinant Proteins)
AC71R787OV (recombinant FVIIa)
EC 3.4.21.21 (Factor VIIa)
Entry Date(s):
Date Created: 20080104 Date Completed: 20080221 Latest Revision: 20181113
Update Code:
20240104
PubMed Central ID:
PMC2170501
PMID:
18172537
Czasopismo naukowe
Recombinant factor VIIa has been licensed in the United Kingdom since 1996 for the control of bleeding in hemophilic patients who are actively bleeding or are about to undergo surgery. Medical practitioners are also applying recombinant factor VIIa toward the control of bleeding in patients without hemophilia. Although the efficacy of recombinant factor VIIa has been shown in many patients, concerns have arisen about the risk of thrombotic adverse events. Herein, we report the case of a 73-year-old woman who underwent major coronary surgery and developed fatal systemic venous thrombosis after recombinant factor VIIa was used in an attempt to control her severe postoperative bleeding. We review the medical literature and discuss the risks of using recombinant factor VIIa to control severe bleeding after cardiac surgery.
Comment in: Tex Heart Inst J. 2008;35(3):373-4; author reply 374-6. (PMID: 18941643)

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