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Tytuł pozycji:

Impaired prepulse inhibition and prepulse-elicited reactivity but intact reflex circuit excitability in unmedicated schizophrenia patients: a comparison with healthy subjects and medicated schizophrenia patients.

Tytuł:
Impaired prepulse inhibition and prepulse-elicited reactivity but intact reflex circuit excitability in unmedicated schizophrenia patients: a comparison with healthy subjects and medicated schizophrenia patients.
Autorzy:
Csomor PA; University Hospital of Psychiatry, Zurich Switzerland. />Yee BK
Feldon J
Theodoridou A
Studerus E
Vollenweider FX
Źródło:
Schizophrenia bulletin [Schizophr Bull] 2009 Jan; Vol. 35 (1), pp. 244-55. Date of Electronic Publication: 2008 Jan 31.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2005- : Cary, NC : Oxford University Press
Original Publication: [Chevy Chase, Md., For sale by the Supt. of Docs., U. S. Govt. Print. Off. Washington]
MeSH Terms:
Health Status*
Reaction Time*
Reflex, Startle*
Antipsychotic Agents/*therapeutic use
Nerve Net/*physiology
Neural Inhibition/*physiology
Reflex/*physiology
Schizophrenia/*drug therapy
Schizophrenia/*physiopathology
Adult ; Electromyography ; Female ; Habituation, Psychophysiologic ; Humans ; Male ; Schizophrenia/epidemiology ; Withholding Treatment/statistics & numerical data
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Substance Nomenclature:
0 (Antipsychotic Agents)
Entry Date(s):
Date Created: 20080205 Date Completed: 20090330 Latest Revision: 20211020
Update Code:
20240104
PubMed Central ID:
PMC2643951
DOI:
10.1093/schbul/sbm146
PMID:
18245063
Czasopismo naukowe
Deficient sensorimotor gating as indexed by prepulse inhibition (PPI) of the startle response has been reported repeatedly in patients suffering from schizophrenia. According to the widely accepted "protective hypothesis," PPI reflects the protection of ongoing information processing against interference by other stimuli. Alternatively, it has been proposed that PPI might be regulated by startle reflex circuit excitability. In the present study, we evaluated these 2 conceptually divergent approaches underlying the regulation of PPI. To this end, we assessed sensorimotor gating as indexed by PPI, the reactivity to the prepulse-alone stimulus indexed as prepulse-elicited reactivity (PPER), and acoustic blink reflex excitability in terms of paired pulse suppression (PPS) within a single recording session in 13 unmedicated and 24 medicated (11 first break) schizophrenia patients in comparison to 43 healthy control subjects. The results showed that PPI was significantly reduced in unmedicated, but not in medicated schizophrenia patients. Furthermore, unmedicated patients could be distinguished from the medicated patients and control subjects in terms of PPER. In contrast to PPI, PPS did not differ between patients and control subjects. These findings are in line with the "protective hypothesis" of PPI and indicate that reduced sensorimotor gating in schizophrenia patients might be based on a reduced perception and/or processing of the prepulse stimulus. The extent to which PPER may or may not be causally associated with sensorimotor gating in schizophrenia has to be further investigated in human and animal studies.

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