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Tytuł pozycji:

Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma.

Tytuł :
Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma.
Autorzy :
Hasegawa Y; Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan. />Goto M
Hanai N
Ijichi K
Terada A
Hyodo I
Ogawa T
Fukushima M
Pokaż więcej
Źródło :
Oncology [Oncology] 2007; Vol. 73 (1-2), pp. 104-11. Date of Electronic Publication: 2008 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Basel, New York, Karger.
MeSH Terms :
Antineoplastic Agents/*pharmacology
Biomarkers, Tumor/*analysis
Carcinoma, Squamous Cell/*chemistry
ErbB Receptors/*analysis
Head and Neck Neoplasms/*chemistry
Receptor, ErbB-2/*analysis
Adult ; Aged ; Aged, 80 and over ; Biopsy ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/surgery ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm ; Drug Screening Assays, Antitumor ; Female ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Reverse Transcriptase Polymerase Chain Reaction
Substance Nomenclature :
0 (Antineoplastic Agents)
0 (Biomarkers, Tumor)
EC 2.7.10.1 (ERBB2 protein, human)
EC 2.7.10.1 (ErbB Receptors)
EC 2.7.10.1 (Receptor, ErbB-2)
Q20Q21Q62J (Cisplatin)
U3P01618RT (Fluorouracil)
Entry Date(s) :
Date Created: 20080314 Date Completed: 20080414 Latest Revision: 20181201
Update Code :
20210210
DOI :
10.1159/000120998
PMID :
18337622
Czasopismo naukowe
Aims: The main purpose of the current study was to find predictive biomarkers that can be routinely used for the response to chemotherapy in head and neck squamous cell carcinoma (HNSCC).
Methods: From this standpoint, we selected the histoculture drug response assay (HDRA) to assess in vitro chemosensitivity, and real-time reverse transcription polymerase chain reaction to investigate the gene expression profile of individual tumors as available predictive biomarkers. Using both surgery and biopsy specimens, we analyzed their gene expression profiles using the 18 markers that we thought were likely predictors of the response to anti-cancer agents.
Results: Statistically significant associations were found between 5-fluorouracil (5-FU) sensitivity in HDRA and HER-2 mRNA expression level (p = 0.0030). Moreover, HER-2 expression was significantly associated with cisplatin sensitivity (p = 0.0089). Cisplatin sensitivity in HDRA was also demonstrated to have a significant association with epidermal growth factor receptor (EGFR) expression in which the group with cisplatin resistance tended to have a higher expression level than the sensitive group (p = 0.0385).
Conclusion: HER-2 and EGFR may be possible reliable predictive biomarkers for anti-cancer therapy, and might help in the decision-making process for individual patients with HNSCC.
((c) 2008 S. Karger AG, Basel)

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