Murine NKT cells produce Th17 cytokine interleukin-22.

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Tytuł:: Murine NKT cells produce Th17 cytokine interleukin-22.
Autorzy:: Goto M; Biomedical Research Laboratories, Asubio Pharma Co., Limited, 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan.
Murakawa M
Kadoshima-Yamaoka K
Tanaka Y
Nagahira K
Fukuda Y
Nishimura T
Źródło:: Cellular immunology [Cell Immunol] 2009; Vol. 254 (2), pp. 81-4. Date of Electronic Publication: 2008 Nov 17.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
MeSH Terms:: Interleukin-17/*immunology
Interleukins/*biosynthesis
Interleukins/*immunology
Natural Killer T-Cells/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Animals ; Cells, Cultured ; Female ; Interleukin-6/pharmacology ; Mice ; Mice, Inbred C57BL ; Natural Killer T-Cells/drug effects ; Natural Killer T-Cells/metabolism ; Spleen/immunology ; Transforming Growth Factor beta/pharmacology ; Interleukin-22
Substance Nomenclature:: 0 (Interleukin-17)
0 (Interleukin-6)
0 (Interleukins)
0 (Transforming Growth Factor beta)
Entry Date(s):: Date Created: 20081118 Date Completed: 20090102 Latest Revision: 20231213
Update Code:: 20240104
DOI:: 10.1016/j.cellimm.2008.10.002
PMID:: 19010461
: Czasopismo naukowe

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Natural killer T (NKT) cells are known to produce Th17 cytokine IL-17 in addition to Th1/2 cytokines. In this study, the ability of NKT cells to produce IL-22, another Th17 cytokine, was examined in mice. When murine spleen cells were stimulated with alpha-galactosyl ceramide, a ligand for NKT cells, not only Th1/2 cytokines (IFN-gamma, IL-4) but Th17 cytokines (IL-17, IL-22) were produced. NKT cells isolated from splenocytes released IL-17 and IL-22 following CD3, CD3/IL-2 or CD3/CD28 stimulation, in which CD3/CD28 costimulation was most effective. Production of IL-17 and IL-22 in CD4+ and CD8+ T cells from splenocytes was little, if any, even after CD3/CD28 costimulation. Treatment with IL-6/TGF-beta decreased CD3/CD28-stimulated production of IL-22, but not that of IL-17, in NKT cells. These findings show for the first time that NKT cells are a cell source of IL-22, and that expression of two Th17 cytokines might be regulated in NKT cells by different mechanisms.

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