[Inhibitory control deficit in patients with panic disorder: an event-related potentials study].

Szczegóły
Abstrakt

Tytuł:: [Inhibitory control deficit in patients with panic disorder: an event-related potentials study].
Autorzy:: Liu XW; Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Xu J
Zhang BW
Zhao L
Li QD
Jiang GJ
Źródło:: Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2008 Nov 11; Vol. 88 (41), pp. 2912-5.
Typ publikacji:: English Abstract; Journal Article; Research Support, Non-U.S. Gov't
Język:: Chinese
Imprint Name(s):: Publication: Beijing : Zhonghua yi xue hui
Original Publication: Beijing : Zhonghua yi xue hui.
MeSH Terms:: Evoked Potentials*
Panic Disorder/*physiopathology
Panic Disorder/*psychology
Adult ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Nerve Net ; Reaction Time
Entry Date(s):: Date Created: 20081217 Date Completed: 20090528 Latest Revision: 20081216
Update Code:: 20240104
PMID:: 19080098
: Czasopismo naukowe

Objective: To investigate the electrophysiological evidence of inhibitory control deficit in panic disorder patients using a visual simple Go/Nogo task.
Method: Sixteen patients with panic disorder and 13 healthy volunteers received a visual simple Go/Nogo task. The stimuli were single or double English letters and appeared with equal probability. The subjects were instructed to press a button as quickly as possible when the double letter was presented (i.e., Go), but make no response to the single letter (i.e., Nogo). 32 channel EEG data were recorded.
Result: All subjects displayed a distinct Go/Nogo effect in the N2 component (PD group:F(1,30) = 8.00, P = 0.008; NC group: F(1,24) = 4.60, P = 0.042) and P3 component (PD group: F(1,30) = 7.85, P = 0.009; NC group: F(1,24) = 13.57, P = 0.000) at frontocentral sites, but the amplitudes of Nogo-N2 and Nogo-P3 were significantly reduced in panic disorder patients as compared to the healthy subjects (Fz: F = 9.135, P = 0.005; F = 8.511, P = 0.006, respectively). There was no significant differences between the latencies of Nogo-N2 and Nogo-P3.
Conclusion: Panic disorder may consist inhibitory control deficit which may assist in offering new objective evidence to understand the etiology of panic disorder.

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