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Tytuł pozycji:

Clinicopathologic characteristics of gastrointestinal stromal tumor of the stomach.

Tytuł:
Clinicopathologic characteristics of gastrointestinal stromal tumor of the stomach.
Autorzy:
Yang HK; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Park DJ
Lee HJ
Kim HH
Kim WH
Lee KU
Źródło:
Hepato-gastroenterology [Hepatogastroenterology] 2008 Sep-Oct; Vol. 55 (86-87), pp. 1925-30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Stuttgart, Thieme.
MeSH Terms:
Gastrointestinal Stromal Tumors/*pathology
Stomach Neoplasms/*pathology
Adult ; Aged ; Benzamides ; Female ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/mortality ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Imatinib Mesylate ; Male ; Middle Aged ; Piperazines/therapeutic use ; Pyrimidines/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery
Substance Nomenclature:
0 (Benzamides)
0 (Piperazines)
0 (Pyrimidines)
8A1O1M485B (Imatinib Mesylate)
Entry Date(s):
Date Created: 20081224 Date Completed: 20090127 Latest Revision: 20160510
Update Code:
20240104
PMID:
19102424
Czasopismo naukowe
Background/aims: This study was undertaken to investigate a surgical role in treating gastrointestinal stromal tumors (GISTs) of the stomach and to find their behavior and prognostic factors.
Methodology: The clinicopathologic results of 112 patients with gastric GISTs who underwent surgery from December 1999 to August 2006 were reviewed.
Results: Forty (35.7%) patients had no symptoms. Of a total of 112 patients, curative resections were performed on 105 (93.8%). There were 41 (36.6%) high-risk patients. The mean follow-up period was 34.3 months (1-82 months) and there were two deaths. Six (5.7%) of the 105 patients who received curative resections had recurrences and all recurrences occurred only in high-risk patients. Univariate analysis showed that tumor size and mitotic count were prognostic for disease-free survival of GIST patients (p=0.0004 and p<0.0001, respectively), but multivariate analysis identified mitotic count as the only prognostic factor for disease-free survival of GIST patients (p=0.039).
Conclusions: The curative resection rate was high in GISTs of the stomach and they were treated using various surgical procedures. Patient survival after curative resection was good. Mitotic count was the independent prognostic factor for disease-free survival and only high-risk patients had recurrences.

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